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| 05.11.2021 | 20:30 | 1. FSV Mainz 05 | - | Bor. Mönchengladbach | 1:1 (0:1) | |
| 06.11.2021 | 15:30 | Bayern München | - | SC Freiburg | 2:1 (1:0) | |
| 15:30 | VfL Wolfsburg | - | FC Augsburg | 1:0 (1:0) | ||
| 15:30 | VfB Stuttgart | - | Arminia Bielefeld | 0:1 (0:1) | ||
| 15:30 | VfL Bochum | - | 1899 Hoffenheim | 2:0 (0:0) | ||
| 18:30 | RB Leipzig | - | Borussia Dortmund | 2:1 (1:0) | ||
| 07.11.2021 | 15:30 | Hertha BSC | - | Bayer Leverkusen | 1:1 (1:0) | |
| 17:30 | 1. FC Köln | - | 1. FC Union Berlin | 2:2 (1:2) | ||
| 19:30 | SpVgg Greuther Fürth | - | Eintracht Frankfurt | 1:2 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 11 | 9 | 1 | 1 | 40:11 | 29 | 28 |
| 2 |
|
Borussia Dortmund | 11 | 8 | 0 | 3 | 28:17 | 11 | 24 |
| 3 |
|
SC Freiburg | 11 | 6 | 4 | 1 | 18:9 | 9 | 22 |
| 4 |
|
VfL Wolfsburg | 11 | 6 | 1 | 4 | 12:12 | 0 | 19 |
| 5 |
|
RB Leipzig | 11 | 5 | 3 | 3 | 23:11 | 12 | 18 |
| 6 |
|
Bayer Leverkusen | 11 | 5 | 3 | 3 | 24:17 | 7 | 18 |
| 7 |
|
1. FSV Mainz 05 | 11 | 5 | 2 | 4 | 15:11 | 4 | 17 |
| 8 |
|
1. FC Union Berlin | 11 | 4 | 5 | 2 | 17:17 | 0 | 17 |
| 9 |
|
Bor. Mönchengladbach | 11 | 4 | 3 | 4 | 13:14 | -1 | 15 |
| 10 |
|
1899 Hoffenheim | 11 | 4 | 2 | 5 | 19:17 | 2 | 14 |
| 11 |
|
1. FC Köln | 11 | 3 | 5 | 3 | 17:20 | -3 | 14 |
| 12 |
|
VfL Bochum | 11 | 4 | 1 | 6 | 10:18 | -8 | 13 |
| 13 |
|
Hertha BSC | 11 | 4 | 1 | 6 | 12:24 | -12 | 13 |
| 14 |
|
Eintracht Frankfurt | 11 | 2 | 6 | 3 | 12:16 | -4 | 12 |
| 15 |
|
VfB Stuttgart | 11 | 2 | 4 | 5 | 15:20 | -5 | 10 |
| 16 |
|
FC Augsburg | 11 | 2 | 3 | 6 | 9:20 | -11 | 9 |
| 17 |
|
Arminia Bielefeld | 11 | 1 | 5 | 5 | 7:16 | -9 | 8 |
| 18 |
|
SpVgg Greuther Fürth | 11 | 0 | 1 | 10 | 8:29 | -21 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
