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| 19.11.2021 | 20:30 | FC Augsburg | - | Bayern München | 2:1 (2:1) | |
| 20.11.2021 | 15:30 | Borussia Dortmund | - | VfB Stuttgart | 2:1 (0:0) | |
| 15:30 | Bayer Leverkusen | - | VfL Bochum | 1:0 (1:0) | ||
| 15:30 | Bor. Mönchengladbach | - | SpVgg Greuther Fürth | 4:0 (3:0) | ||
| 15:30 | 1899 Hoffenheim | - | RB Leipzig | 2:0 (1:0) | ||
| 15:30 | Arminia Bielefeld | - | VfL Wolfsburg | 2:2 (1:0) | ||
| 18:30 | 1. FC Union Berlin | - | Hertha BSC | 2:0 (2:0) | ||
| 21.11.2021 | 15:30 | SC Freiburg | - | Eintracht Frankfurt | 0:2 (0:2) | |
| 17:30 | 1. FSV Mainz 05 | - | 1. FC Köln | 1:1 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 12 | 9 | 1 | 2 | 41:13 | 28 | 28 |
| 2 |
|
Borussia Dortmund | 12 | 9 | 0 | 3 | 30:18 | 12 | 27 |
| 3 |
|
SC Freiburg | 12 | 6 | 4 | 2 | 18:11 | 7 | 22 |
| 4 |
|
Bayer Leverkusen | 12 | 6 | 3 | 3 | 25:17 | 8 | 21 |
| 5 |
|
1. FC Union Berlin | 12 | 5 | 5 | 2 | 19:17 | 2 | 20 |
| 6 |
|
VfL Wolfsburg | 12 | 6 | 2 | 4 | 14:14 | 0 | 20 |
| 7 |
|
RB Leipzig | 12 | 5 | 3 | 4 | 23:13 | 10 | 18 |
| 8 |
|
1. FSV Mainz 05 | 12 | 5 | 3 | 4 | 16:12 | 4 | 18 |
| 9 |
|
Bor. Mönchengladbach | 12 | 5 | 3 | 4 | 17:14 | 3 | 18 |
| 10 |
|
1899 Hoffenheim | 12 | 5 | 2 | 5 | 21:17 | 4 | 17 |
| 11 |
|
Eintracht Frankfurt | 12 | 3 | 6 | 3 | 14:16 | -2 | 15 |
| 12 |
|
1. FC Köln | 12 | 3 | 6 | 3 | 18:21 | -3 | 15 |
| 13 |
|
VfL Bochum | 12 | 4 | 1 | 7 | 10:19 | -9 | 13 |
| 14 |
|
Hertha BSC | 12 | 4 | 1 | 7 | 12:26 | -14 | 13 |
| 15 |
|
FC Augsburg | 12 | 3 | 3 | 6 | 11:21 | -10 | 12 |
| 16 |
|
VfB Stuttgart | 12 | 2 | 4 | 6 | 16:22 | -6 | 10 |
| 17 |
|
Arminia Bielefeld | 12 | 1 | 6 | 5 | 9:18 | -9 | 9 |
| 18 |
|
SpVgg Greuther Fürth | 12 | 0 | 1 | 11 | 8:33 | -25 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
