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| 29.10.2021 | 20:30 | 1899 Hoffenheim | - | Hertha BSC | 2:0 (2:0) | |
| 30.10.2021 | 15:30 | Borussia Dortmund | - | 1. FC Köln | 2:0 (1:0) | |
| 15:30 | Bayer Leverkusen | - | VfL Wolfsburg | 0:2 (0:0) | ||
| 15:30 | 1. FC Union Berlin | - | Bayern München | 2:5 (1:3) | ||
| 15:30 | SC Freiburg | - | SpVgg Greuther Fürth | 3:1 (2:0) | ||
| 15:30 | Arminia Bielefeld | - | 1. FSV Mainz 05 | 1:2 (1:1) | ||
| 18:30 | Eintracht Frankfurt | - | RB Leipzig | 1:1 (0:1) | ||
| 31.10.2021 | 15:30 | FC Augsburg | - | VfB Stuttgart | 4:1 (1:1) | |
| 17:30 | Bor. Mönchengladbach | - | VfL Bochum | 2:1 (2:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 10 | 8 | 1 | 1 | 38:10 | 28 | 25 |
| 2 |
|
Borussia Dortmund | 10 | 8 | 0 | 2 | 27:15 | 12 | 24 |
| 3 |
|
SC Freiburg | 10 | 6 | 4 | 0 | 17:7 | 10 | 22 |
| 4 |
|
Bayer Leverkusen | 10 | 5 | 2 | 3 | 23:16 | 7 | 17 |
| 5 |
|
1. FSV Mainz 05 | 10 | 5 | 1 | 4 | 14:10 | 4 | 16 |
| 6 |
|
1. FC Union Berlin | 10 | 4 | 4 | 2 | 15:15 | 0 | 16 |
| 7 |
|
VfL Wolfsburg | 10 | 5 | 1 | 4 | 11:12 | -1 | 16 |
| 8 |
|
RB Leipzig | 10 | 4 | 3 | 3 | 21:10 | 11 | 15 |
| 9 |
|
1899 Hoffenheim | 10 | 4 | 2 | 4 | 19:15 | 4 | 14 |
| 10 |
|
Bor. Mönchengladbach | 10 | 4 | 2 | 4 | 12:13 | -1 | 14 |
| 11 |
|
1. FC Köln | 10 | 3 | 4 | 3 | 15:18 | -3 | 13 |
| 12 |
|
Hertha BSC | 10 | 4 | 0 | 6 | 11:23 | -12 | 12 |
| 13 |
|
VfB Stuttgart | 10 | 2 | 4 | 4 | 15:19 | -4 | 10 |
| 14 |
|
VfL Bochum | 10 | 3 | 1 | 6 | 8:18 | -10 | 10 |
| 15 |
|
Eintracht Frankfurt | 10 | 1 | 6 | 3 | 10:15 | -5 | 9 |
| 16 |
|
FC Augsburg | 10 | 2 | 3 | 5 | 9:19 | -10 | 9 |
| 17 |
|
Arminia Bielefeld | 10 | 0 | 5 | 5 | 6:16 | -10 | 5 |
| 18 |
|
SpVgg Greuther Fürth | 10 | 0 | 1 | 9 | 7:27 | -20 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
