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| 22.10.2021 | 20:30 | 1. FSV Mainz 05 | - | FC Augsburg | 4:1 (3:0) | |
| 23.10.2021 | 15:30 | Bayern München | - | 1899 Hoffenheim | 4:0 (2:0) | |
| 15:30 | RB Leipzig | - | SpVgg Greuther Fürth | 4:1 (0:1) | ||
| 15:30 | VfL Wolfsburg | - | SC Freiburg | 0:2 (0:1) | ||
| 15:30 | Arminia Bielefeld | - | Borussia Dortmund | 1:3 (0:2) | ||
| 18:30 | Hertha BSC | - | Bor. Mönchengladbach | 1:0 (1:0) | ||
| 24.10.2021 | 15:30 | 1. FC Köln | - | Bayer Leverkusen | 2:2 (0:2) | |
| 17:30 | VfB Stuttgart | - | 1. FC Union Berlin | 1:1 (0:1) | ||
| 19:30 | VfL Bochum | - | Eintracht Frankfurt | 2:0 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 9 | 7 | 1 | 1 | 33:8 | 25 | 22 |
| 2 |
|
Borussia Dortmund | 9 | 7 | 0 | 2 | 25:15 | 10 | 21 |
| 3 |
|
SC Freiburg | 9 | 5 | 4 | 0 | 14:6 | 8 | 19 |
| 4 |
|
Bayer Leverkusen | 9 | 5 | 2 | 2 | 23:14 | 9 | 17 |
| 5 |
|
1. FC Union Berlin | 9 | 4 | 4 | 1 | 13:10 | 3 | 16 |
| 6 |
|
RB Leipzig | 9 | 4 | 2 | 3 | 20:9 | 11 | 14 |
| 7 |
|
1. FSV Mainz 05 | 9 | 4 | 1 | 4 | 12:9 | 3 | 13 |
| 8 |
|
1. FC Köln | 9 | 3 | 4 | 2 | 15:16 | -1 | 13 |
| 9 |
|
VfL Wolfsburg | 9 | 4 | 1 | 4 | 9:12 | -3 | 13 |
| 10 |
|
Hertha BSC | 9 | 4 | 0 | 5 | 11:21 | -10 | 12 |
| 11 |
|
1899 Hoffenheim | 9 | 3 | 2 | 4 | 17:15 | 2 | 11 |
| 12 |
|
Bor. Mönchengladbach | 9 | 3 | 2 | 4 | 10:12 | -2 | 11 |
| 13 |
|
VfB Stuttgart | 9 | 2 | 4 | 3 | 14:15 | -1 | 10 |
| 14 |
|
VfL Bochum | 9 | 3 | 1 | 5 | 7:16 | -9 | 10 |
| 15 |
|
Eintracht Frankfurt | 9 | 1 | 5 | 3 | 9:14 | -5 | 8 |
| 16 |
|
FC Augsburg | 9 | 1 | 3 | 5 | 5:18 | -13 | 6 |
| 17 |
|
Arminia Bielefeld | 9 | 0 | 5 | 4 | 5:14 | -9 | 5 |
| 18 |
|
SpVgg Greuther Fürth | 9 | 0 | 1 | 8 | 6:24 | -18 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
