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| 17.10.2021 | 15:00 | Holzwickeder SC | - | Sportfreunde Siegen | 0:2 (0:1) | |
| 15:00 | RSV Meinerzhagen | - | TuS Haltern | 2:3 (1:2) | ||
| 15:00 | ASC 09 Dortmund | - | Hammer SpVg | 3:0 (1:0) | ||
| 15:00 | Westfalia Rhynern | - | SpVgg Vreden | 6:0 (2:0) | ||
| 15:00 | 1. FC Kaan-Marienborn | - | FCE Rheine | 5:2 (2:1) | ||
| 15:00 | Viktoria Clarholz | - | SG Wattenscheid 09 | 1:2 (1:0) | ||
| 15:00 | SC Paderborn 07 II | - | TuS Erndtebrück | 5:0 (3:0) | ||
| 15:00 | SG Finnentrop/Bamenohl | - | TSG Sprockhövel | 2:1 (0:1) | ||
| 15:15 | Westfalia Herne | - | FC Gütersloh | 1:2 (1:1) | ||
| 15:15 | TuS Ennepetal | - | SV Schermbeck | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Paderborn 07 II | 8 | 6 | 1 | 1 | 26:6 | 20 | 19 |
| 2 |
|
1. FC Kaan-Marienborn | 7 | 6 | 1 | 0 | 22:6 | 16 | 19 |
| 3 |
|
SG Wattenscheid 09 | 8 | 6 | 0 | 2 | 16:10 | 6 | 18 |
| 4 |
|
FCE Rheine | 8 | 6 | 0 | 2 | 12:10 | 2 | 18 |
| 5 |
|
Westfalia Rhynern | 8 | 5 | 0 | 3 | 25:13 | 12 | 15 |
| 6 |
|
TSG Sprockhövel | 8 | 4 | 2 | 2 | 23:11 | 12 | 14 |
| 7 |
|
ASC 09 Dortmund | 8 | 4 | 2 | 2 | 19:13 | 6 | 14 |
| 8 |
|
FC Gütersloh | 7 | 4 | 2 | 1 | 12:6 | 6 | 14 |
| 9 |
|
SV Schermbeck | 8 | 3 | 2 | 3 | 15:11 | 4 | 11 |
| 10 |
|
TuS Ennepetal | 7 | 3 | 2 | 2 | 13:13 | 0 | 11 |
| 11 |
|
Sportfreunde Siegen | 8 | 3 | 2 | 3 | 11:12 | -1 | 11 |
| 12 |
|
Preußen Münster II | 7 | 3 | 1 | 3 | 12:13 | -1 | 10 |
| 13 |
|
TuS Haltern | 7 | 2 | 3 | 2 | 10:12 | -2 | 9 |
| 14 |
|
TuS Erndtebrück | 7 | 2 | 3 | 2 | 10:14 | -4 | 9 |
| 15 |
|
SpVgg Vreden | 8 | 2 | 2 | 4 | 8:21 | -13 | 8 |
| 16 |
|
Hammer SpVg | 8 | 2 | 1 | 5 | 14:18 | -4 | 7 |
| 17 |
|
Holzwickeder SC | 8 | 2 | 1 | 5 | 9:21 | -12 | 7 |
| 18 |
|
SG Finnentrop/Bamenohl | 7 | 1 | 2 | 4 | 8:19 | -11 | 5 |
| 19 |
|
RSV Meinerzhagen | 8 | 1 | 0 | 7 | 9:21 | -12 | 3 |
| 20 |
|
Viktoria Clarholz | 7 | 0 | 2 | 5 | 8:15 | -7 | 2 |
| 21 |
|
Westfalia Herne | 8 | 0 | 1 | 7 | 5:22 | -17 | 1 |
| Play-off | |
| Relégation |
