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| 09.04.2022 | 12:00 | Holstein Kiel | - | FC St. Pauli | 0:1 (0:0) | |
| 13:00 | Hallescher FC | - | 1. FC Union Berlin | 0:4 (0:3) | ||
| 13:00 | FC Carl Zeiss Jena | - | Hannover 96 | 1:2 (1:1) | ||
| 13:00 | Chemnitzer FC | - | Dynamo Dresden | 1:0 (1:0) | ||
| 13:00 | Hansa Rostock | - | FC Viktoria 1889 Berlin | 1:0 (1:0) | ||
| 13:00 | Hertha Zehlendorf | - | Erzgebirge Aue | 1:0 (0:0) | ||
| 13:00 | Hamburger SV | - | RB Leipzig | 1:2 (0:0) | ||
| 13:00 | Werder Bremen | - | Energie Cottbus | 5:5 (2:1) | ||
| 13:00 | Eintracht Braunschweig | - | Hertha BSC | 0:5 (0:4) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 17 | 15 | 2 | 0 | 56:8 | 48 | 47 |
| 2 |
|
FC St. Pauli | 17 | 12 | 2 | 3 | 37:11 | 26 | 38 |
| 3 |
|
Hamburger SV | 17 | 11 | 3 | 3 | 38:16 | 22 | 36 |
| 4 |
|
Chemnitzer FC | 17 | 11 | 1 | 5 | 26:18 | 8 | 34 |
| 5 |
|
VfL Wolfsburg | 17 | 9 | 5 | 3 | 41:20 | 21 | 32 |
| 6 |
|
Dynamo Dresden | 17 | 10 | 1 | 6 | 31:20 | 11 | 31 |
| 7 |
|
RB Leipzig | 17 | 9 | 3 | 5 | 32:22 | 10 | 30 |
| 8 |
|
Werder Bremen | 17 | 9 | 2 | 6 | 42:32 | 10 | 29 |
| 9 |
|
1. FC Union Berlin | 18 | 9 | 2 | 7 | 26:21 | 5 | 29 |
| 10 |
|
Hannover 96 | 17 | 9 | 2 | 6 | 25:27 | -2 | 29 |
| 11 |
|
Hansa Rostock | 17 | 7 | 2 | 8 | 23:27 | -4 | 23 |
| 12 |
|
FC Viktoria 1889 Berlin | 17 | 7 | 0 | 10 | 22:30 | -8 | 21 |
| 13 |
|
Holstein Kiel | 17 | 4 | 3 | 10 | 24:38 | -14 | 15 |
| 14 |
|
Energie Cottbus | 17 | 4 | 3 | 10 | 22:45 | -23 | 15 |
| 15 |
|
Erzgebirge Aue | 17 | 3 | 5 | 9 | 12:29 | -17 | 14 |
| 16 |
|
FC Carl Zeiss Jena | 17 | 4 | 1 | 12 | 11:26 | -15 | 13 |
| 17 |
|
Hertha Zehlendorf | 17 | 4 | 0 | 13 | 16:30 | -14 | 12 |
| 18 |
|
Eintracht Braunschweig | 17 | 2 | 4 | 11 | 11:33 | -22 | 10 |
| 19 |
|
Hallescher FC | 17 | 1 | 3 | 13 | 9:51 | -42 | 6 |
| Play-off | |
| Relégation |
