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| 19.02.2022 | 11:00 | SV Darmstadt 98 | - | 1. FC Heidenheim 1846 | 0:0 (0:0) | |
| 11:00 | FC Ingolstadt 04 | - | Bayern München | 1:4 (0:3) | ||
| 12:00 | Karlsruher SC | - | 1. FC Saarbrücken | 3:1 (2:1) | ||
| 13:00 | 1. FC Nürnberg | - | 1899 Hoffenheim | 1:4 (1:2) | ||
| 13:00 | SpVgg Unterhaching | - | SSV Ulm 1846 | 6:3 (3:3) | ||
| 14:00 | 1. FC Kaiserslautern | - | SC Freiburg | 1:4 (1:2) | ||
| 15:30 | SpVgg Greuther Fürth | - | Eintracht Frankfurt | 2:3 (1:3) | ||
| 20.02.2022 | 11:00 | FC-Astoria Walldorf | - | FC Augsburg | 1:3 (0:2) | |
| 13:00 | Stuttgarter Kickers | - | Kickers Offenbach | 0:3 (0:0) | ||
| 13:00 | 1. FSV Mainz 05 | - | VfB Stuttgart | 0:3 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 14 | 11 | 2 | 1 | 44:10 | 34 | 35 |
| 2 |
|
1. FC Nürnberg | 15 | 10 | 1 | 4 | 31:23 | 8 | 31 |
| 3 |
|
FC Augsburg | 14 | 9 | 3 | 2 | 40:23 | 17 | 30 |
| 4 |
|
Eintracht Frankfurt | 14 | 9 | 2 | 3 | 40:19 | 21 | 29 |
| 5 |
|
1. FSV Mainz 05 | 15 | 9 | 1 | 5 | 43:28 | 15 | 28 |
| 6 |
|
1899 Hoffenheim | 14 | 8 | 3 | 3 | 49:25 | 24 | 27 |
| 7 |
|
SpVgg Unterhaching | 14 | 8 | 2 | 4 | 27:23 | 4 | 26 |
| 8 |
|
Bayern München | 14 | 8 | 1 | 5 | 45:20 | 25 | 25 |
| 9 |
|
1. FC Heidenheim 1846 | 15 | 7 | 3 | 5 | 29:20 | 9 | 24 |
| 10 |
|
SC Freiburg | 15 | 6 | 4 | 5 | 30:28 | 2 | 22 |
| 11 |
|
Karlsruher SC | 14 | 5 | 6 | 3 | 25:20 | 5 | 21 |
| 12 |
|
FC Ingolstadt 04 | 14 | 5 | 4 | 5 | 26:23 | 3 | 19 |
| 13 |
|
1. FC Kaiserslautern | 14 | 6 | 0 | 8 | 28:41 | -13 | 18 |
| 14 |
|
SV Darmstadt 98 | 14 | 4 | 5 | 5 | 16:23 | -7 | 17 |
| 15 |
|
FC-Astoria Walldorf | 14 | 3 | 6 | 5 | 23:27 | -4 | 15 |
| 16 |
|
Kickers Offenbach | 15 | 4 | 1 | 10 | 20:38 | -18 | 13 |
| 17 |
|
SpVgg Greuther Fürth | 15 | 3 | 3 | 9 | 20:37 | -17 | 12 |
| 18 |
|
Stuttgarter Kickers | 14 | 3 | 2 | 9 | 20:41 | -21 | 11 |
| 19 |
|
SSV Ulm 1846 | 14 | 3 | 1 | 10 | 20:38 | -18 | 10 |
| 20 |
|
1. FC Saarbrücken | 14 | 3 | 0 | 11 | 11:29 | -18 | 9 |
| 21 |
|
Hessen Kassel | 14 | 1 | 0 | 13 | 6:57 | -51 | 3 |
| Play-off | |
| Relégation |
