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| 02.04.2022 | 11:00 | Werder Bremen | - | Dynamo Dresden | 4:2 (1:2) | |
| 12:30 | Energie Cottbus | - | FC Carl Zeiss Jena | 3:0 (1:0) | ||
| 13:00 | 1. FC Magdeburg | - | Chemnitzer FC | 4:0 (0:0) | ||
| 13:30 | 1. FC Union Berlin | - | RB Leipzig | 1:2 (1:0) | ||
| 14:00 | VfL Wolfsburg | - | FC Viktoria 1889 Berlin | 1:0 (1:0) | ||
| 15:00 | Hamburger SV | - | FC St. Pauli | 2:1 (1:1) | ||
| 15:00 | Hertha BSC | - | Eimsbütteler TV | 5:1 (4:1) | ||
| 03.04.2022 | 11:00 | Hansa Rostock | - | VfL Osnabrück | 0:1 (0:1) | |
| 11:00 | Hannover 96 | - | Holstein Kiel | 0:1 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 15 | 12 | 1 | 2 | 42:20 | 22 | 37 |
| 2 |
|
Energie Cottbus | 15 | 11 | 2 | 2 | 29:15 | 14 | 35 |
| 3 |
|
Werder Bremen | 15 | 10 | 1 | 4 | 39:29 | 10 | 31 |
| 4 |
|
RB Leipzig | 15 | 9 | 3 | 3 | 38:18 | 20 | 30 |
| 5 |
|
Holstein Kiel | 15 | 9 | 2 | 4 | 25:21 | 4 | 29 |
| 6 |
|
FC Viktoria 1889 Berlin | 15 | 6 | 6 | 3 | 25:18 | 7 | 24 |
| 7 |
|
VfL Wolfsburg | 16 | 6 | 5 | 5 | 20:20 | 0 | 23 |
| 8 |
|
1. FC Union Berlin | 15 | 6 | 4 | 5 | 23:23 | 0 | 22 |
| 9 |
|
1. FC Magdeburg | 15 | 6 | 1 | 8 | 30:26 | 4 | 19 |
| 10 |
|
Dynamo Dresden | 15 | 6 | 1 | 8 | 22:19 | 3 | 19 |
| 11 |
|
Hannover 96 | 15 | 5 | 4 | 6 | 20:20 | 0 | 19 |
| 12 |
|
Hamburger SV | 15 | 5 | 4 | 6 | 26:30 | -4 | 19 |
| 13 |
|
Hansa Rostock | 15 | 5 | 3 | 7 | 27:21 | 6 | 18 |
| 14 |
|
Hallescher FC | 15 | 5 | 3 | 7 | 15:29 | -14 | 18 |
| 15 |
|
Chemnitzer FC | 15 | 4 | 4 | 7 | 16:25 | -9 | 16 |
| 16 |
|
VfL Osnabrück | 15 | 4 | 4 | 7 | 17:28 | -11 | 16 |
| 17 |
|
FC St. Pauli | 16 | 4 | 3 | 9 | 23:35 | -12 | 15 |
| 18 |
|
Eimsbütteler TV | 15 | 2 | 3 | 10 | 14:32 | -18 | 9 |
| 19 |
|
FC Carl Zeiss Jena | 16 | 1 | 2 | 13 | 12:34 | -22 | 5 |
| Play-off | |
| Relégation |
