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| 02.10.2021 | 11:00 | FSV Frankfurt | - | Eintracht Frankfurt | 1:2 (0:0) | |
| 03.10.2021 | 11:00 | SpVgg Unterhaching | - | SV Darmstadt 98 | 4:0 (3:0) | |
| 11:00 | 1. FSV Mainz 05 | - | 1. FC Kaiserslautern | 4:4 (1:1) | ||
| 11:00 | SV 07 Elversberg | - | TSV 1860 München | 0:1 (0:0) | ||
| 11:00 | 1. FC Nürnberg | - | SC Freiburg | 1:4 (0:3) | ||
| 13:00 | Stuttgarter Kickers | - | FC Ingolstadt 04 | 4:2 (3:0) | ||
| 14:00 | SV Wehen Wiesbaden | - | 1899 Hoffenheim | 2:6 (1:2) | ||
| 14:00 | FC Augsburg | - | SpVgg Greuther Fürth | 3:1 (2:0) | ||
| 14:00 | Bayern München | - | SSV Reutlingen | 6:0 (0:0) | ||
| 16.12.2021 | 18:30 | VfB Stuttgart | - | 1. FC Heidenheim 1846 | 4:2 (3:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 7 | 6 | 1 | 0 | 29:10 | 19 | 19 |
| 2 |
|
SpVgg Unterhaching | 7 | 6 | 0 | 1 | 21:9 | 12 | 18 |
| 3 |
|
1899 Hoffenheim | 6 | 5 | 0 | 1 | 22:10 | 12 | 15 |
| 4 |
|
SC Freiburg | 7 | 5 | 0 | 2 | 19:8 | 11 | 15 |
| 5 |
|
Bayern München | 6 | 4 | 0 | 2 | 20:8 | 12 | 12 |
| 6 |
|
1. FSV Mainz 05 | 7 | 3 | 3 | 1 | 19:10 | 9 | 12 |
| 7 |
|
FC Augsburg | 6 | 4 | 0 | 2 | 15:12 | 3 | 12 |
| 8 |
|
Eintracht Frankfurt | 7 | 3 | 2 | 2 | 12:12 | 0 | 11 |
| 9 |
|
TSV 1860 München | 6 | 3 | 1 | 2 | 9:8 | 1 | 10 |
| 10 |
|
Stuttgarter Kickers | 6 | 3 | 0 | 3 | 11:15 | -4 | 9 |
| 11 |
|
SV Darmstadt 98 | 7 | 3 | 0 | 4 | 11:18 | -7 | 9 |
| 12 |
|
Karlsruher SC | 6 | 2 | 2 | 2 | 7:8 | -1 | 8 |
| 13 |
|
1. FC Heidenheim 1846 | 6 | 2 | 2 | 2 | 13:18 | -5 | 8 |
| 14 |
|
1. FC Kaiserslautern | 7 | 2 | 1 | 4 | 20:17 | 3 | 7 |
| 15 |
|
1. FC Nürnberg | 7 | 2 | 1 | 4 | 13:13 | 0 | 7 |
| 16 |
|
FSV Frankfurt | 7 | 2 | 1 | 4 | 9:12 | -3 | 7 |
| 17 |
|
SpVgg Greuther Fürth | 7 | 2 | 1 | 4 | 7:11 | -4 | 7 |
| 18 |
|
SV 07 Elversberg | 7 | 2 | 0 | 5 | 7:16 | -9 | 6 |
| 19 |
|
FC Ingolstadt 04 | 7 | 1 | 2 | 4 | 8:20 | -12 | 5 |
| 20 |
|
SV Wehen Wiesbaden | 7 | 1 | 0 | 6 | 9:22 | -13 | 3 |
| 21 |
|
SSV Reutlingen | 7 | 0 | 1 | 6 | 4:28 | -24 | 1 |
| Play-off | |
| Relégation |
