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| 14.08.2021 | 00:00 | Colón de Santa Fe | - | Gimnasia de La Plata | 1:0 (0:0) | |
| 02:15 | Huracán | - | Unión de Santa Fe | 0:0 (0:0) | ||
| 18:30 | Atlético Tucumán | - | Aldosivi | 2:2 (0:1) | ||
| 20:45 | Argentinos Juniors | - | Banfield | 2:0 (0:0) | ||
| 23:00 | River Plate | - | Vélez Sarsfield | 2:0 (0:0) | ||
| 15.08.2021 | 01:15 | Rosario Central | - | Independiente | 1:2 (0:2) | |
| 18:30 | Patronato de Paraná | - | Central Córdoba SdE | 1:0 (0:0) | ||
| 20:45 | Platense | - | Arsenal de Sarandí | 2:1 (2:0) | ||
| 23:00 | Estudiantes | - | Boca Juniors | 1:0 (0:0) | ||
| 16.08.2021 | 01:15 | Racing Club | - | Newell's Old Boys | 2:0 (0:0) | |
| 23:00 | Talleres de Córdoba | - | San Lorenzo | 2:0 (2:0) | ||
| 17.08.2021 | 01:15 | Defensa y Justicia | - | Sarmiento de Junín | 4:2 (2:1) | |
| 02:45 | Lanús | - | Godoy Cruz | 3:1 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Independiente | 6 | 4 | 2 | 0 | 7:2 | 5 | 14 |
| 2 |
|
Lanús | 6 | 4 | 1 | 1 | 13:8 | 5 | 13 |
| 3 |
|
Colón de Santa Fe | 6 | 4 | 1 | 1 | 7:6 | 1 | 13 |
| 4 |
|
Estudiantes | 6 | 4 | 0 | 2 | 12:6 | 6 | 12 |
| 5 |
|
Racing Club | 6 | 3 | 2 | 1 | 5:1 | 4 | 11 |
| 6 |
|
Patronato de Paraná | 6 | 3 | 2 | 1 | 7:4 | 3 | 11 |
| 7 |
|
River Plate | 6 | 3 | 1 | 2 | 12:5 | 7 | 10 |
| 8 |
|
Talleres de Córdoba | 6 | 3 | 1 | 2 | 8:5 | 3 | 10 |
| 9 |
|
Newell's Old Boys | 6 | 3 | 1 | 2 | 8:7 | 1 | 10 |
| 10 |
|
Aldosivi | 6 | 3 | 1 | 2 | 6:7 | -1 | 10 |
| 11 |
|
Argentinos Juniors | 6 | 2 | 3 | 1 | 5:3 | 2 | 9 |
| 12 |
|
Godoy Cruz | 6 | 3 | 0 | 3 | 8:9 | -1 | 9 |
| 13 |
|
Gimnasia de La Plata | 6 | 2 | 2 | 2 | 6:6 | 0 | 8 |
| 14 |
|
Atlético Tucumán | 6 | 2 | 2 | 2 | 7:8 | -1 | 8 |
| 15 |
|
San Lorenzo | 6 | 2 | 2 | 2 | 5:8 | -3 | 8 |
| 16 |
|
Defensa y Justicia | 6 | 2 | 1 | 3 | 9:9 | 0 | 7 |
| 17 |
|
Unión de Santa Fe | 6 | 1 | 3 | 2 | 6:7 | -1 | 6 |
| 18 |
|
Huracán | 6 | 1 | 3 | 2 | 4:5 | -1 | 6 |
| 19 |
|
Banfield | 6 | 1 | 3 | 2 | 3:5 | -2 | 6 |
| 20 |
|
Sarmiento de Junín | 6 | 2 | 0 | 4 | 4:10 | -6 | 6 |
| 21 |
|
Central Córdoba SdE | 6 | 1 | 2 | 3 | 5:7 | -2 | 5 |
|
Platense | 6 | 1 | 2 | 3 | 5:7 | -2 | 5 | |
| 23 |
|
Arsenal de Sarandí | 6 | 1 | 2 | 3 | 5:11 | -6 | 5 |
| 24 |
|
Boca Juniors | 6 | 0 | 4 | 2 | 2:5 | -3 | 4 |
| 25 |
|
Rosario Central | 6 | 1 | 0 | 5 | 4:8 | -4 | 3 |
| 26 |
|
Vélez Sarsfield | 6 | 0 | 3 | 3 | 0:4 | -4 | 3 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
