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| 20.08.2021 | 21:45 | Aldosivi | - | Colón de Santa Fe | 3:0 (1:0) | |
| 21.08.2021 | 00:00 | Banfield | - | Estudiantes | 1:1 (0:1) | |
| 00:00 | Sarmiento de Junín | - | Atlético Tucumán | 3:0 (0:0) | ||
| 02:30 | Independiente | - | Defensa y Justicia | 0:0 (0:0) | ||
| 18:00 | Central Córdoba SdE | - | Platense | 2:2 (2:0) | ||
| 18:30 | Godoy Cruz | - | Huracán | 1:1 (1:1) | ||
| 20:45 | Vélez Sarsfield | - | Lanús | 5:1 (1:0) | ||
| 23:00 | Arsenal de Sarandí | - | Racing Club | 0:3 (0:1) | ||
| 22.08.2021 | 01:15 | Boca Juniors | - | Patronato de Paraná | 1:0 (0:0) | |
| 18:30 | Unión de Santa Fe | - | Talleres de Córdoba | 1:2 (0:1) | ||
| 20:45 | Newell's Old Boys | - | Rosario Central | 1:1 (0:0) | ||
| 23:00 | San Lorenzo | - | Argentinos Juniors | 0:1 (0:1) | ||
| 23.08.2021 | 01:15 | Gimnasia de La Plata | - | River Plate | 1:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Independiente | 7 | 4 | 3 | 0 | 7:2 | 5 | 15 |
| 2 |
|
Racing Club | 7 | 4 | 2 | 1 | 8:1 | 7 | 14 |
| 3 |
|
Estudiantes | 7 | 4 | 1 | 2 | 13:7 | 6 | 13 |
| 4 |
|
Talleres de Córdoba | 7 | 4 | 1 | 2 | 10:6 | 4 | 13 |
| 5 |
|
Aldosivi | 7 | 4 | 1 | 2 | 9:7 | 2 | 13 |
| 6 |
|
Lanús | 7 | 4 | 1 | 2 | 14:13 | 1 | 13 |
| 7 |
|
Colón de Santa Fe | 7 | 4 | 1 | 2 | 7:9 | -2 | 13 |
| 8 |
|
Argentinos Juniors | 7 | 3 | 3 | 1 | 6:3 | 3 | 12 |
| 9 |
|
River Plate | 7 | 3 | 2 | 2 | 13:6 | 7 | 11 |
| 10 |
|
Patronato de Paraná | 7 | 3 | 2 | 2 | 7:5 | 2 | 11 |
| 11 |
|
Newell's Old Boys | 7 | 3 | 2 | 2 | 9:8 | 1 | 11 |
| 12 |
|
Godoy Cruz | 7 | 3 | 1 | 3 | 9:10 | -1 | 10 |
| 13 |
|
Gimnasia de La Plata | 7 | 2 | 3 | 2 | 7:7 | 0 | 9 |
| 14 |
|
Sarmiento de Junín | 7 | 3 | 0 | 4 | 7:10 | -3 | 9 |
| 15 |
|
Defensa y Justicia | 7 | 2 | 2 | 3 | 9:9 | 0 | 8 |
| 16 |
|
Atlético Tucumán | 7 | 2 | 2 | 3 | 7:11 | -4 | 8 |
| 17 |
|
San Lorenzo | 7 | 2 | 2 | 3 | 5:9 | -4 | 8 |
| 18 |
|
Huracán | 7 | 1 | 4 | 2 | 5:6 | -1 | 7 |
| 19 |
|
Banfield | 7 | 1 | 4 | 2 | 4:6 | -2 | 7 |
| 20 |
|
Boca Juniors | 7 | 1 | 4 | 2 | 3:5 | -2 | 7 |
| 21 |
|
Vélez Sarsfield | 7 | 1 | 3 | 3 | 5:5 | 0 | 6 |
| 22 |
|
Central Córdoba SdE | 7 | 1 | 3 | 3 | 7:9 | -2 | 6 |
|
Platense | 7 | 1 | 3 | 3 | 7:9 | -2 | 6 | |
|
Unión de Santa Fe | 7 | 1 | 3 | 3 | 7:9 | -2 | 6 | |
| 25 |
|
Arsenal de Sarandí | 7 | 1 | 2 | 4 | 5:14 | -9 | 5 |
| 26 |
|
Rosario Central | 7 | 1 | 1 | 5 | 5:9 | -4 | 4 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
