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| 17.03.2022 | 13:00 | Gimnasia de La Plata II | - | Estudiantes II | 2:1 (0:1) | |
| 13:00 | Lanús II | - | Banfield II | 1:1 (1:1) | ||
| 15:00 | Colón de Santa Fe II | - | Unión de Santa Fe II | 0:1 (0:0) | ||
| 18.03.2022 | 13:00 | Defensa y Justicia II | - | Arsenal de Sarandí II | 3:1 (1:0) | |
| 13:00 | River Plate II | - | Boca Juniors II | 0:0 (0:0) | ||
| 13:00 | Talleres de Córdoba II | - | Godoy Cruz II | 7:0 (3:0) | ||
| 13:00 | Aldosivi II | - | Patronato de Paraná II | 1:0 (1:0) | ||
| 13:00 | Barracas Central II | - | Sarmiento de Junín II | 0:2 (0:1) | ||
| 15:00 | Rosario Central II | - | Newell's Old Boys II | 2:1 (1:1) | ||
| 20.03.2022 | 14:30 | Argentinos Juniors II | - | Vélez Sarsfield II | 3:3 (1:2) | |
| 21.03.2022 | 13:00 | San Lorenzo II | - | Huracán II | 0:0 (0:0) | |
| 13:00 | Atlético Tucumán II | - | Central Córdoba SdE II | 2:2 (1:2) | ||
| 15:00 | Tigre II | - | Platense II | 4:1 (3:0) | ||
| 22.03.2022 | 13:00 | Independiente II | - | Racing Club II | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Banfield II | 7 | 5 | 2 | 0 | 13:7 | 6 | 17 |
| 2 |
|
Gimnasia de La Plata II | 7 | 5 | 0 | 2 | 16:11 | 5 | 15 |
| 3 |
|
Defensa y Justicia II | 7 | 5 | 0 | 2 | 11:6 | 5 | 15 |
| 4 |
|
River Plate II | 7 | 4 | 2 | 1 | 13:7 | 6 | 14 |
| 5 |
|
Sarmiento de Junín II | 7 | 4 | 1 | 2 | 10:6 | 4 | 13 |
| 6 |
|
Talleres de Córdoba II | 7 | 3 | 3 | 1 | 20:8 | 12 | 12 |
| 7 |
|
Argentinos Juniors II | 7 | 3 | 2 | 2 | 11:6 | 5 | 11 |
| 8 |
|
Atlético Tucumán II | 7 | 3 | 1 | 3 | 15:15 | 0 | 10 |
| 9 |
|
Newell's Old Boys II | 7 | 2 | 2 | 3 | 11:11 | 0 | 8 |
| 10 |
|
Unión de Santa Fe II | 7 | 2 | 2 | 3 | 3:12 | -9 | 8 |
| 11 |
|
Platense II | 7 | 1 | 2 | 4 | 9:13 | -4 | 5 |
| 12 |
|
Patronato de Paraná II | 7 | 1 | 1 | 5 | 5:10 | -5 | 4 |
| 13 |
|
San Lorenzo II | 7 | 1 | 1 | 5 | 5:16 | -11 | 4 |
| 14 |
|
Racing Club II | 7 | 1 | 0 | 6 | 10:18 | -8 | 3 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tigre II | 7 | 4 | 3 | 0 | 14:4 | 10 | 15 |
| 2 |
|
Central Córdoba SdE II | 7 | 4 | 2 | 1 | 12:7 | 5 | 14 |
| 3 |
|
Aldosivi II | 7 | 4 | 1 | 2 | 12:7 | 5 | 13 |
| 4 |
|
Rosario Central II | 7 | 3 | 2 | 2 | 13:7 | 6 | 11 |
| 5 |
|
Arsenal de Sarandí II | 7 | 3 | 2 | 2 | 8:8 | 0 | 11 |
| 6 |
|
Independiente II | 7 | 2 | 4 | 1 | 9:6 | 3 | 10 |
| 7 |
|
Estudiantes II | 7 | 3 | 1 | 3 | 11:11 | 0 | 10 |
| 8 |
|
Lanús II | 7 | 2 | 3 | 2 | 9:9 | 0 | 9 |
| 9 |
|
Vélez Sarsfield II | 7 | 2 | 3 | 2 | 10:11 | -1 | 9 |
| 10 |
|
Huracán II | 7 | 2 | 2 | 3 | 10:8 | 2 | 8 |
| 11 |
|
Boca Juniors II | 7 | 1 | 5 | 1 | 5:5 | 0 | 8 |
| 12 |
|
Colón de Santa Fe II | 7 | 2 | 1 | 4 | 5:8 | -3 | 7 |
| 13 |
|
Barracas Central II | 7 | 2 | 0 | 5 | 7:17 | -10 | 6 |
| 14 |
|
Godoy Cruz II | 7 | 0 | 0 | 7 | 2:25 | -23 | 0 |
| Play-off | |
| Play-off |
