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| 31.03.2022 | 14:00 | Boca Juniors II | - | Arsenal de Sarandí II | 3:1 (0:0) | |
| 14:00 | Central Córdoba SdE II | - | Huracán II | 1:0 (0:0) | ||
| 16:00 | Vélez Sarsfield II | - | Lanús II | 2:3 (1:2) | ||
| 16:00 | Colón de Santa Fe II | - | Aldosivi II | 1:0 (0:0) | ||
| 01.04.2022 | 14:00 | Defensa y Justicia II | - | River Plate II | 2:0 (1:0) | |
| 14:00 | Patronato de Paraná II | - | Unión de Santa Fe II | 1:1 (0:1) | ||
| 16:00 | Gimnasia de La Plata II | - | Talleres de Córdoba II | 2:1 (2:1) | ||
| 16:00 | Tigre II | - | Rosario Central II | 1:3 (1:1) | ||
| 02.04.2022 | 16:00 | Godoy Cruz II | - | Estudiantes II | 2:3 (1:1) | |
| 03.04.2022 | 15:00 | Barracas Central II | - | Independiente II | 3:1 (1:1) | |
| 04.04.2022 | 14:00 | San Lorenzo II | - | Atlético Tucumán II | 1:1 (0:1) | |
| 14:00 | Racing Club II | - | Sarmiento de Junín II | 1:1 (0:1) | ||
| 14:00 | Newell's Old Boys II | - | Platense II | 1:2 (1:2) | ||
| 16:00 | Banfield II | - | Argentinos Juniors II | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Banfield II | 8 | 6 | 2 | 0 | 14:7 | 7 | 20 |
| 2 |
|
Defensa y Justicia II | 8 | 6 | 0 | 2 | 13:6 | 7 | 18 |
| 3 |
|
Gimnasia de La Plata II | 8 | 6 | 0 | 2 | 18:12 | 6 | 18 |
| 4 |
|
River Plate II | 8 | 4 | 2 | 2 | 13:9 | 4 | 14 |
| 5 |
|
Sarmiento de Junín II | 8 | 4 | 2 | 2 | 11:7 | 4 | 14 |
| 6 |
|
Talleres de Córdoba II | 8 | 3 | 3 | 2 | 21:10 | 11 | 12 |
| 7 |
|
Argentinos Juniors II | 8 | 3 | 2 | 3 | 11:7 | 4 | 11 |
| 8 |
|
Atlético Tucumán II | 8 | 3 | 2 | 3 | 16:16 | 0 | 11 |
| 9 |
|
Unión de Santa Fe II | 8 | 2 | 3 | 3 | 4:13 | -9 | 9 |
| 10 |
|
Newell's Old Boys II | 8 | 2 | 2 | 4 | 12:13 | -1 | 8 |
| 11 |
|
Platense II | 8 | 2 | 2 | 4 | 11:14 | -3 | 8 |
| 12 |
|
Patronato de Paraná II | 8 | 1 | 2 | 5 | 6:11 | -5 | 5 |
| 13 |
|
San Lorenzo II | 8 | 1 | 2 | 5 | 6:17 | -11 | 5 |
| 14 |
|
Racing Club II | 8 | 1 | 1 | 6 | 11:19 | -8 | 4 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Central Córdoba SdE II | 8 | 5 | 2 | 1 | 13:7 | 6 | 17 |
| 2 |
|
Tigre II | 8 | 4 | 3 | 1 | 15:7 | 8 | 15 |
| 3 |
|
Rosario Central II | 8 | 4 | 2 | 2 | 16:8 | 8 | 14 |
| 4 |
|
Aldosivi II | 8 | 4 | 1 | 3 | 12:8 | 4 | 13 |
| 5 |
|
Estudiantes II | 8 | 4 | 1 | 3 | 14:13 | 1 | 13 |
| 6 |
|
Lanús II | 8 | 3 | 3 | 2 | 12:11 | 1 | 12 |
| 7 |
|
Boca Juniors II | 8 | 2 | 5 | 1 | 8:6 | 2 | 11 |
| 8 |
|
Arsenal de Sarandí II | 8 | 3 | 2 | 3 | 9:11 | -2 | 11 |
| 9 |
|
Independiente II | 8 | 2 | 4 | 2 | 10:9 | 1 | 10 |
| 10 |
|
Colón de Santa Fe II | 8 | 3 | 1 | 4 | 6:8 | -2 | 10 |
| 11 |
|
Vélez Sarsfield II | 8 | 2 | 3 | 3 | 12:14 | -2 | 9 |
| 12 |
|
Barracas Central II | 8 | 3 | 0 | 5 | 10:18 | -8 | 9 |
| 13 |
|
Huracán II | 8 | 2 | 2 | 4 | 10:9 | 1 | 8 |
| 14 |
|
Godoy Cruz II | 8 | 0 | 0 | 8 | 4:28 | -24 | 0 |
| Play-off | |
| Play-off |
