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| 23.04.2022 | 13:00 | FC St. Pauli | - | FC Carl Zeiss Jena | 2:0 (2:0) | |
| 13:00 | Hamburger SV | - | VfL Osnabrück | 4:1 (2:1) | ||
| 13:00 | Energie Cottbus | - | Holstein Kiel | 2:1 (2:0) | ||
| 13:00 | Hansa Rostock | - | RB Leipzig | 1:3 (1:1) | ||
| 13:00 | Hannover 96 | - | Chemnitzer FC | 1:0 (0:0) | ||
| 13:00 | 1. FC Union Berlin | - | Eimsbütteler TV | 0:3 (0:2) | ||
| 13:00 | 1. FC Magdeburg | - | Dynamo Dresden | 2:2 (1:2) | ||
| 13:00 | Hertha BSC | - | FC Viktoria 1889 Berlin | 1:0 (0:0) | ||
| 13:00 | Werder Bremen | - | Hallescher FC | 2:3 (2:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 17 | 13 | 2 | 2 | 44:21 | 23 | 41 |
| 2 |
|
Energie Cottbus | 17 | 12 | 2 | 3 | 31:18 | 13 | 38 |
| 3 |
|
RB Leipzig | 17 | 11 | 3 | 3 | 43:19 | 24 | 36 |
| 4 |
|
Werder Bremen | 17 | 10 | 1 | 6 | 42:36 | 6 | 31 |
| 5 |
|
Holstein Kiel | 17 | 9 | 2 | 6 | 26:25 | 1 | 29 |
| 6 |
|
FC Viktoria 1889 Berlin | 17 | 7 | 6 | 4 | 29:20 | 9 | 27 |
| 7 |
|
VfL Wolfsburg | 17 | 7 | 5 | 5 | 21:20 | 1 | 26 |
| 8 |
|
Hamburger SV | 17 | 7 | 4 | 6 | 35:31 | 4 | 25 |
| 9 |
|
1. FC Union Berlin | 17 | 7 | 4 | 6 | 25:26 | -1 | 25 |
| 10 |
|
Hannover 96 | 17 | 6 | 4 | 7 | 21:22 | -1 | 22 |
| 11 |
|
Hansa Rostock | 17 | 6 | 3 | 8 | 30:24 | 6 | 21 |
| 12 |
|
1. FC Magdeburg | 17 | 6 | 3 | 8 | 33:29 | 4 | 21 |
| 13 |
|
Dynamo Dresden | 17 | 6 | 3 | 8 | 25:22 | 3 | 21 |
| 14 |
|
Hallescher FC | 17 | 6 | 3 | 8 | 18:32 | -14 | 21 |
| 15 |
|
VfL Osnabrück | 17 | 5 | 4 | 8 | 20:32 | -12 | 19 |
| 16 |
|
FC St. Pauli | 17 | 5 | 3 | 9 | 25:35 | -10 | 18 |
| 17 |
|
Chemnitzer FC | 17 | 4 | 4 | 9 | 16:28 | -12 | 16 |
| 18 |
|
Eimsbütteler TV | 17 | 3 | 4 | 10 | 18:33 | -15 | 13 |
| 19 |
|
FC Carl Zeiss Jena | 18 | 1 | 2 | 15 | 12:41 | -29 | 5 |
| Play-off | |
| Relégation |
