| 6. Journée | 16.08.2021 | Racing Club | - | Newell's Old Boys | 2:0 | ||||
| 7. Journée | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 |  |
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| 9. Journée | 30.08.2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Journée | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 11. Journée | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 18. Journée | 25.10.2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 | ||||
| 19. Journée | 31.10.2021 | Newell's Old Boys | - | Independiente | 1:0 | ||||
| 20. Journée | 08.11.2021 | Newell's Old Boys | - | Unión de Santa Fe | 1:0 |  |
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| 21. Journée | 21.11.2021 | Arsenal de Sarandí | - | Newell's Old Boys | 3:1 | ||||
| 22. Journée | 24.11.2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 | ||||
| 23. Journée | 30.11.2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | |
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| 24. Journée | 07.12.2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Journée | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 | |
Argentine