| 1. Journée | 12.02.2022 | Unión de Santa Fe | - | River Plate | 1:0 |  |
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| 2. Journée | 17.02.2022 | River Plate | - | Patronato de Paraná | 4:1 | ||||
| 3. Journée | 21.02.2022 | Newell's Old Boys | - | River Plate | 0:2 | ||||
| 4. Journée | 27.02.2022 | River Plate | - | Racing Club | 2:2 | ||||
| 5. Journée | 05.03.2022 | San Lorenzo | - | River Plate | 0:1 | ||||
| 6. Journée | 13.03.2022 | River Plate | - | Gimnasia de La Plata | 4:0 | ||||
| 7. Journée | 20.03.2022 | River Plate | - | Boca Juniors | 0:1 | ||||
| 8. Journée | 03.04.2022 | Defensa y Justicia | - | River Plate | 1:2 | ||||
| 9. Journée | 11.04.2022 | River Plate | - | Argentinos Juniors | 4:2 | ||||
| 10. Journée | 18.04.2022 | Banfield | - | River Plate | 1:2 | ||||
| 11. Journée | 21.04.2022 | Talleres de Córdoba | - | River Plate | 1:0 | ||||
| 12. Journée | 25.04.2022 | River Plate | - | Atlético Tucumán | 1:1 | ||||
| 13. Journée | 01.05.2022 | Sarmiento de Junín | - | River Plate | 0:7 |
Argentine
