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| 18.03.2022 | 20:00 | Aldosivi | - | Patronato de Paraná | 3:1 (2:1) | |
| 23:15 | Tigre | - | Platense | 4:0 (3:0) | ||
| 19.03.2022 | 01:30 | Barracas Central | - | Sarmiento de Junín | 2:1 (0:0) | |
| 18:00 | Lanús | - | Banfield | 0:1 (0:0) | ||
| 20:15 | San Lorenzo | - | Huracán | 0:0 (0:0) | ||
| 22:30 | Colón de Santa Fe | - | Unión de Santa Fe | 0:0 (0:0) | ||
| 20.03.2022 | 00:45 | Independiente | - | Racing Club | 1:2 (0:1) | |
| 18:00 | Rosario Central | - | Newell's Old Boys | 0:1 (0:0) | ||
| 20:15 | Gimnasia de La Plata | - | Estudiantes | 1:1 (0:1) | ||
| 23:00 | River Plate | - | Boca Juniors | 0:1 (0:0) | ||
| 21.03.2022 | 23:15 | Defensa y Justicia | - | Arsenal de Sarandí | 1:1 (1:0) | |
| 22.03.2022 | 01:30 | Argentinos Juniors | - | Vélez Sarsfield | 1:0 (0:0) | |
| 23:15 | Atlético Tucumán | - | Central Córdoba SdE | 0:1 (0:1) | ||
| 23.03.2022 | 01:30 | Talleres de Córdoba | - | Godoy Cruz | 2:1 (1:1) |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Club | 7 | 4 | 3 | 0 | 14:5 | 9 | 15 |
| 2 |
|
Defensa y Justicia | 7 | 4 | 2 | 1 | 14:11 | 3 | 14 |
| 3 |
|
Unión de Santa Fe | 7 | 4 | 2 | 1 | 6:3 | 3 | 14 |
| 4 |
|
River Plate | 7 | 4 | 1 | 2 | 13:5 | 8 | 13 |
| 5 |
|
Newell's Old Boys | 7 | 4 | 1 | 2 | 10:8 | 2 | 13 |
| 6 |
|
Banfield | 7 | 3 | 2 | 2 | 11:7 | 4 | 11 |
| 7 |
|
Argentinos Juniors | 7 | 3 | 2 | 2 | 8:7 | 1 | 11 |
| 8 |
|
Sarmiento de Junín | 7 | 3 | 2 | 2 | 9:9 | 0 | 11 |
| 9 |
|
Platense | 7 | 2 | 1 | 4 | 6:10 | -4 | 7 |
| 10 |
|
San Lorenzo | 7 | 1 | 3 | 3 | 5:7 | -2 | 6 |
| 11 |
|
Gimnasia de La Plata | 7 | 1 | 3 | 3 | 6:14 | -8 | 6 |
| 12 |
|
Talleres de Córdoba | 7 | 1 | 2 | 4 | 3:6 | -3 | 5 |
| 13 |
|
Patronato de Paraná | 7 | 1 | 1 | 5 | 4:11 | -7 | 4 |
| 14 |
|
Atlético Tucumán | 7 | 1 | 1 | 5 | 3:13 | -10 | 4 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 7 | 4 | 2 | 1 | 12:9 | 3 | 14 |
| 2 |
|
Boca Juniors | 7 | 4 | 2 | 1 | 9:6 | 3 | 14 |
| 3 |
|
Tigre | 7 | 3 | 3 | 1 | 9:3 | 6 | 12 |
| 4 |
|
Colón de Santa Fe | 7 | 3 | 3 | 1 | 9:5 | 4 | 12 |
| 5 |
|
Aldosivi | 7 | 3 | 1 | 3 | 8:7 | 1 | 10 |
| 6 |
|
Huracán | 7 | 3 | 1 | 3 | 8:8 | 0 | 10 |
| 7 |
|
Central Córdoba SdE | 7 | 2 | 3 | 2 | 6:6 | 0 | 9 |
| 8 |
|
Barracas Central | 7 | 3 | 0 | 4 | 9:12 | -3 | 9 |
| 9 |
|
Godoy Cruz | 7 | 2 | 2 | 3 | 11:13 | -2 | 8 |
| 10 |
|
Independiente | 7 | 1 | 4 | 2 | 9:10 | -1 | 7 |
| 11 |
|
Arsenal de Sarandí | 7 | 1 | 4 | 2 | 8:9 | -1 | 7 |
| 12 |
|
Rosario Central | 7 | 2 | 1 | 4 | 6:9 | -3 | 7 |
| 13 |
|
Lanús | 7 | 1 | 3 | 3 | 6:7 | -1 | 6 |
| 14 |
|
Vélez Sarsfield | 7 | 1 | 3 | 3 | 3:5 | -2 | 6 |
| Play-off | |
| Play-off |
