H (Match allé) Omonia Nikosia - FC Flora -:-
R (match retour) FC Flora - Omonia Nikosia -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Lud. Razgrad / NŠ Mura - FK Žalgiris -:-
R (match retour) FK Žalgiris - Lud. Razgrad / NŠ Mura -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Crvena Zvezda / FK Kairat - FC Alashkert / FC Sheriff -:-
R (match retour) FC Alashkert / FC Sheriff - Crvena Zvezda / FK Kairat -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Cluj / Lincoln Red Imps - Young Boys / Slovan Bratislava -:-
R (match retour) Young Boys / Slovan Bratislava - Cluj / Lincoln Red Imps -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Olympiakos / Neftci - HJK Helsinki -:-
R (match retour) HJK Helsinki - Olympiakos / Neftci -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) FK Jablonec - Celtic / Midtjylland -:-
R (match retour) Celtic / Midtjylland - FK Jablonec -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Sparta Praha / Rapid Wien - Anorthosis Famagusta -:-
R (match retour) Anorthosis Famagusta - Sparta Praha / Rapid Wien -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) PSV / Galatasaray - St. Johnstone FC -:-
R (match retour) St. Johnstone FC - PSV / Galatasaray -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021