H (Match allé) Dinamo Tbilisi / Maccabi Haifa - HB Tórshavn -:-
R (match retour) HB Tórshavn - Dinamo Tbilisi / Maccabi Haifa -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Linfield / Banja Luka - Shakhter Soligorsk / Fola Esch -:-
R (match retour) Shakhter Soligorsk / Fola Esch - Linfield / Banja Luka -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Shamrock Rovers - KF Teuta Durrës -:-
R (match retour) KF Teuta Durrës - Shamrock Rovers -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Riga FC / Shkëndija - Hibernians FC -:-
R (match retour) Hibernians FC - Riga FC / Shkëndija -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Prishtina / Connah's Quay - Valur / Bodø/Glimt -:-
R (match retour) Valur / Bodø/Glimt - Prishtina / Connah's Quay -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Dinamo Batumi / BATE Borisov - Petrocub / Sivasspor -:-
R (match retour) Petrocub / Sivasspor - Dinamo Batumi / BATE Borisov -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Kuopion/ Vorskla Poltava - Astana / Aris Saloniki -:-
R (match retour) Astana / Aris Saloniki - Kuopion/ Vorskla Poltava -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Sochi / Keşlə - Partizan / Dunajská Streda -:-
R (match retour) Partizan / Dunajská Streda - Sochi / Keşlə -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Shkupi / Santa Clara - Ljubljana / Birkirkara -:-
R (match retour) Ljubljana / Birkirkara - Shkupi / Santa Clara -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Újpest / Vaduz - FC Basel / Partizani -:-
R (match retour) FC Basel / Partizani - Újpest / Vaduz -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Kolos Kovalivka - FCSB / Shakter Karaganda -:-
R (match retour) FCSB / Shakter Karaganda - Kolos Kovalivka -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Elfsborg / Milsami - V. Mostar / AEK -:-
R (match retour) V. Mostar / AEK - Elfsborg / Milsami -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Paços de Ferreira - Larne / Aarhus -:-
R (match retour) Larne / Aarhus - Paços de Ferreira -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) FC Luzern - Drita / Feyenoord -:-
R (match retour) Drita / Feyenoord - FC Luzern -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Rīgas FS / Puskás - Gent / Vålerenga -:-
R (match retour) Gent / Vålerenga - Rīgas FS / Puskás -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Hibernian / Santa Coloma - Gżira / Rijeka -:-
R (match retour) Gżira / Rijeka - Hibernian / Santa Coloma -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Austria Wien / Breiðablik - Aberdeen / Häcken -:-
R (match retour) Aberdeen / Häcken - Austria Wien / Breiðablik -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Trabzonspor - Molde / Servette -:-
R (match retour) Molde / Servette - Trabzonspor -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Dudelange / Bohemians - PAOK Saloniki -:-
R (match retour) PAOK Saloniki - Dudelange / Bohemians -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Kauno Žalgiris / New Saints - Vikt. Plzeň / Dinamo Brest -:-
R (match retour) Vikt. Plzeň / Dinamo Brest - Kauno Žalgiris / New Saints -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Sūduva / Raków Częstochowa - Rubin Kazan -:-
R (match retour) Rubin Kazan - Sūduva / Raków Częstochowa -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Lok. Plovdiv / Slovácko - København / Torpedo-B. Zhodino -:-
R (match retour) København / Torpedo-B. Zhodino - Lok. Plovdiv / Slovácko -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Hajduk Split / Tobyl Kostanay - Apollon Limassol / Žilina -:-
R (match retour) Apollon Limassol / Žilina - Hajduk Split / Tobyl Kostanay -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) CSKA Sofia / Liepāja - Pogoń Szczecin / Osijek -:-
R (match retour) Pogoń Szczecin / Osijek - CSKA Sofia / Liepāja -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Panevėžys / Vojvodina - LASK -:-
R (match retour) LASK - Panevėžys / Vojvodina -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) AEL Limassol / Vllaznia - Qarabağ / Ashdod -:-
R (match retour) Qarabağ / Ashdod - AEL Limassol / Vllaznia -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Spartak Trnava / Sepsi OSK - Sutjeska / Maccabi Tel Aviv -:-
R (match retour) Sutjeska / Maccabi Tel Aviv - Spartak Trnava / Sepsi OSK -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Hafnarfjörður / Rosenborg - Domžale / Honka -:-
R (match retour) Domžale / Honka - Hafnarfjörður / Rosenborg -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Laçi / U. Craiova - RSC Anderlecht -:-
R (match retour) RSC Anderlecht - Laçi / U. Craiova -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Vitesse - Dundalk / Levadia -:-
R (match retour) Dundalk / Levadia - Vitesse -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Čukarički / Sumgayit - Hammarby / Maribor -:-
R (match retour) Hammarby / Maribor - Čukarički / Sumgayit -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021
H (Match allé) Ararat / Śląsk Wrocław - Arda Kardzhali / Be'er Sheva -:-
R (match retour) Arda Kardzhali / Be'er Sheva - Ararat / Śląsk Wrocław -:-
H (Match allé): 05.08.2021 R (match retour): 12.08.2021