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| 26.02.2022 | 15:00 | Slovan Liberec | - | FK Jablonec | 1:1 (0:0) | |
| 15:00 | 1. FC Slovácko | - | FK Mladá Boleslav | 2:1 (0:1) | ||
| 15:00 | Bohemians Praha 1905 | - | Baník Ostrava | 0:2 (0:0) | ||
| 18:00 | Viktoria Plzeň | - | FK Pardubice | 4:0 (2:0) | ||
| 27.02.2022 | 15:00 | MFK Karviná | - | Dynamo České Budějovice | 2:2 (1:0) | |
| 15:00 | FC Hradec Králové | - | Slavia Praha | 1:5 (0:4) | ||
| 15:00 | Sigma Olomouc | - | FK Teplice | 0:0 (0:0) | ||
| 18:00 | AC Sparta Praha | - | FC Fastav Zlín | 2:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praha | 23 | 18 | 3 | 2 | 58:16 | 42 | 57 |
| 2 |
|
Viktoria Plzeň | 23 | 18 | 3 | 2 | 44:15 | 29 | 57 |
| 3 |
|
AC Sparta Praha | 23 | 15 | 6 | 2 | 51:25 | 26 | 51 |
| 4 |
|
Baník Ostrava | 23 | 13 | 6 | 4 | 49:31 | 18 | 45 |
| 5 |
|
1. FC Slovácko | 23 | 13 | 4 | 6 | 40:25 | 15 | 43 |
| 6 |
|
Slovan Liberec | 23 | 8 | 5 | 10 | 25:32 | -7 | 29 |
| 7 |
|
Dynamo České Budějovice | 23 | 7 | 7 | 9 | 30:35 | -5 | 28 |
| 8 |
|
FK Mladá Boleslav | 23 | 8 | 3 | 12 | 36:38 | -2 | 27 |
| 9 |
|
FC Hradec Králové | 23 | 6 | 9 | 8 | 27:34 | -7 | 27 |
| 10 |
|
Sigma Olomouc | 23 | 6 | 8 | 9 | 33:31 | 2 | 26 |
| 11 |
|
FC Fastav Zlín | 23 | 7 | 4 | 12 | 26:40 | -14 | 25 |
| 12 |
|
FK Jablonec | 23 | 4 | 10 | 9 | 18:37 | -19 | 22 |
| 13 |
|
FK Teplice | 23 | 6 | 3 | 14 | 25:39 | -14 | 21 |
| 14 |
|
Bohemians Praha 1905 | 23 | 6 | 3 | 14 | 28:48 | -20 | 21 |
| 15 |
|
FK Pardubice | 23 | 4 | 7 | 12 | 25:49 | -24 | 19 |
| 16 |
|
MFK Karviná | 23 | 1 | 7 | 15 | 20:40 | -20 | 10 |
| Play-off | |
| Play-off | |
| Relégation |
