| tour des 16 | 10.03.2022 | Vitesse | - | AS Roma | 0:1 |  |
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| Quarts de finale | 07.04.2022 | FK Bodø/Glimt | - | AS Roma | 2:1 | ||||
| Quarts de finale | 14.04.2022 | AS Roma | - | FK Bodø/Glimt | 4:0 | ||||
| Demi-finales | 28.04.2022 | Leicester City | - | AS Roma | 1:1 | ||||
| Demi-finales | 05.05.2022 | AS Roma | - | Leicester City | 1:0 | ||||
| Finale | 25.05.2022 | AS Roma | - | Feyenoord | 1:0 |
Portugal
