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| H (Match allé) | Leicester City | - | AS Roma | 1:1 (0:1) | ||
| R (match retour) | AS Roma | - | Leicester City | 1:0 (1:0) | ||
| H (Match allé): 28.04.2022 21:00 | R (match retour): 05.05.2022 21:00 | vainqueur: AS Roma | ||||
| H (Match allé) | Feyenoord | - | Olympique Marseille | 3:2 (2:2) | ||
| R (match retour) | Olympique Marseille | - | Feyenoord | 0:0 (0:0) | ||
| H (Match allé): 28.04.2022 21:00 | R (match retour): 05.05.2022 21:00 | vainqueur: Feyenoord | ||||
