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| 16.10.2021 | 13:00 | Etimesgut Belediyespor | - | Sarıyer SK | 1:0 (1:0) | |
| 17.10.2021 | 13:00 | Bayburt İl Özel İdare | - | Çorum FK | 1:2 (0:1) | |
| 13:00 | Ergene Velimeşe | - | Inegölspor | 2:1 (1:1) | ||
| 13:00 | Kahramanmaraşspor | - | Vanspor FK | 0:3 (0:2) | ||
| 13:00 | Sivas Belediyespor | - | Bodrumspor | 0:0 (0:0) | ||
| 13:00 | Turgutluspor | - | Ankaraspor | 4:3 (1:3) | ||
| 15:30 | Sakaryaspor | - | Hekimoğlu Trabzon | 0:0 (0:0) | ||
| 18:00 | Afjet Afyonspor | - | Adıyamanspor | 1:0 (0:0) | ||
| 18:00 | Diyarbekirspor | - | Niğde Anadolu FK | 3:0 (3:0) | ||
| 18:00 | Serik Belediyespor | - | Somaspor | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Vanspor FK | 8 | 6 | 2 | 0 | 17:6 | 11 | 20 |
| 2 |
|
Sivas Belediyespor | 8 | 5 | 3 | 0 | 14:1 | 13 | 18 |
| 3 |
|
Hekimoğlu Trabzon | 8 | 5 | 3 | 0 | 15:4 | 11 | 18 |
| 4 |
|
Bodrumspor | 8 | 5 | 1 | 2 | 15:4 | 11 | 16 |
| 5 |
|
Çorum FK | 8 | 4 | 3 | 1 | 10:4 | 6 | 15 |
| 6 |
|
Ankaraspor | 8 | 4 | 2 | 2 | 19:9 | 10 | 14 |
| 7 |
|
Sakaryaspor | 8 | 3 | 5 | 0 | 8:2 | 6 | 14 |
| 8 |
|
Bayburt İl Özel İdare | 8 | 4 | 2 | 2 | 9:7 | 2 | 14 |
| 9 |
|
Afjet Afyonspor | 8 | 3 | 4 | 1 | 14:11 | 3 | 13 |
| 10 |
|
Etimesgut Belediyespor | 8 | 4 | 1 | 3 | 11:11 | 0 | 13 |
| 11 |
|
Serik Belediyespor | 8 | 4 | 0 | 4 | 8:11 | -3 | 12 |
| 12 |
|
Inegölspor | 8 | 3 | 2 | 3 | 13:12 | 1 | 11 |
| 13 |
|
Somaspor | 8 | 3 | 2 | 3 | 11:11 | 0 | 11 |
| 14 |
|
Sarıyer SK | 8 | 3 | 1 | 4 | 10:11 | -1 | 10 |
| 15 |
|
Diyarbekirspor | 8 | 2 | 1 | 5 | 8:10 | -2 | 7 |
| 16 |
|
Turgutluspor | 8 | 1 | 2 | 5 | 9:16 | -7 | 5 |
| 17 |
|
Ergene Velimeşe | 8 | 1 | 1 | 6 | 5:20 | -15 | 4 |
| 18 |
|
Niğde Anadolu FK | 8 | 1 | 1 | 6 | 3:20 | -17 | 4 |
| 19 |
|
Adıyamanspor | 8 | 1 | 0 | 7 | 7:16 | -9 | 3 |
| 20 |
|
Kahramanmaraşspor | 8 | 0 | 0 | 8 | 3:23 | -20 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
