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| 10.10.2021 | 12:30 | Adıyamanspor | - | Etimesgut Belediyespor | 3:0 (1:0) | |
| 13:30 | Hekimoğlu Trabzon | - | Ergene Velimeşe | 3:1 (0:1) | ||
| 13:30 | Vanspor FK | - | Serik Belediyespor | 2:0 (0:0) | ||
| 14:00 | Niğde Anadolu FK | - | Afjet Afyonspor | 0:0 (0:0) | ||
| 14:30 | Bodrumspor | - | Kahramanmaraşspor | 4:0 (2:0) | ||
| 14:30 | Inegölspor | - | Diyarbekirspor | 1:0 (1:0) | ||
| 14:30 | Sarıyer SK | - | Bayburt İl Özel İdare | 3:0 (3:0) | ||
| 14:30 | Somaspor | - | Turgutluspor | 1:1 (1:0) | ||
| 18:00 | Ankaraspor | - | Sakaryaspor | 1:1 (1:1) | ||
| 18:00 | Çorum FK | - | Sivas Belediyespor | 0:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sivas Belediyespor | 7 | 5 | 2 | 0 | 14:1 | 13 | 17 |
| 2 |
|
Hekimoğlu Trabzon | 7 | 5 | 2 | 0 | 15:4 | 11 | 17 |
| 3 |
|
Vanspor FK | 7 | 5 | 2 | 0 | 14:6 | 8 | 17 |
| 4 |
|
Bodrumspor | 7 | 5 | 0 | 2 | 15:4 | 11 | 15 |
| 5 |
|
Ankaraspor | 7 | 4 | 2 | 1 | 16:5 | 11 | 14 |
| 6 |
|
Bayburt İl Özel İdare | 7 | 4 | 2 | 1 | 8:5 | 3 | 14 |
| 7 |
|
Sakaryaspor | 7 | 3 | 4 | 0 | 8:2 | 6 | 13 |
| 8 |
|
Çorum FK | 7 | 3 | 3 | 1 | 8:3 | 5 | 12 |
| 9 |
|
Inegölspor | 7 | 3 | 2 | 2 | 12:10 | 2 | 11 |
| 10 |
|
Somaspor | 7 | 3 | 2 | 2 | 11:10 | 1 | 11 |
| 11 |
|
Afjet Afyonspor | 7 | 2 | 4 | 1 | 13:11 | 2 | 10 |
| 12 |
|
Sarıyer SK | 7 | 3 | 1 | 3 | 10:10 | 0 | 10 |
| 13 |
|
Etimesgut Belediyespor | 7 | 3 | 1 | 3 | 10:11 | -1 | 10 |
| 14 |
|
Serik Belediyespor | 7 | 3 | 0 | 4 | 7:11 | -4 | 9 |
| 15 |
|
Diyarbekirspor | 7 | 1 | 1 | 5 | 5:10 | -5 | 4 |
| 16 |
|
Niğde Anadolu FK | 7 | 1 | 1 | 5 | 3:17 | -14 | 4 |
| 17 |
|
Adıyamanspor | 7 | 1 | 0 | 6 | 7:15 | -8 | 3 |
| 18 |
|
Turgutluspor | 7 | 0 | 2 | 5 | 5:13 | -8 | 2 |
| 19 |
|
Ergene Velimeşe | 7 | 0 | 1 | 6 | 3:19 | -16 | 1 |
| 20 |
|
Kahramanmaraşspor | 7 | 0 | 0 | 7 | 3:20 | -17 | 0 |
| Promotion | |
| Play-off | |
| Relégation |
