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| 20.12.2022 | 20:45 | Wolverhampton Wanderers | - | Gillingham FC | 2:0 (0:0) | |
| 20:45 | Southampton FC | - | Lincoln City | 2:1 (1:1) | ||
| 20:45 | Newcastle United | - | AFC Bournemouth | 1:0 (0:0) | ||
| 20:45 | Milton Keynes Dons | - | Leicester City | 0:3 (0:2) | ||
| 21.12.2022 | 20:45 | Blackburn Rovers | - | Nottingham Forest | 1:4 (1:1) | |
| 20:45 | Charlton Athletic | - | Brighton & Hove Albion | 4:3 (0:0, 0:0) tab | ||
| 21:00 | Manchester United | - | Burnley FC | 2:0 (1:0) | ||
| 22.12.2022 | 21:00 | Manchester City | - | Liverpool FC | 3:2 (1:1) |
