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| 16.07.2022 | 01:30 | Gimnasia y Esgrima (CdU) | - | Crucero del Norte | 1:0 (1:0) | |
| 01:30 | Belgrano de San Francisco | - | Atlético Paraná | 4:1 (1:0) | ||
| 02:00 | Racing de Córdoba | - | Sportivo Las Parejas | 2:1 (1:1) | ||
| 19:30 | Douglas Haig | - | Unión de Sunchales | 3:1 (1:1) | ||
| 19:30 | Juventud Unida de Gualeguaychú | - | Juventud Antoniana | 2:2 (2:0) | ||
| 20:00 | Defensores Belgrano (VR) | - | Defensores de Pronunciamiento | 1:0 (1:0) | ||
| 20:05 | Sarmiento de Resistencia | - | Gimnasia y Tiro de Salta | 2:0 (2:0) | ||
| 17.07.2022 | 03:00 | Central Norte | - | San Martín de Formosa | 3:3 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 18 | 11 | 7 | 0 | 33:8 | 25 | 40 |
| 2 |
|
Central Norte | 17 | 9 | 7 | 1 | 25:11 | 14 | 34 |
| 3 |
|
Sarmiento de Resistencia | 18 | 9 | 7 | 2 | 21:9 | 12 | 34 |
| 4 |
|
Douglas Haig | 18 | 9 | 5 | 4 | 27:13 | 14 | 32 |
| 5 |
|
San Martín de Formosa | 18 | 8 | 5 | 5 | 29:21 | 8 | 29 |
| 6 |
|
Gimnasia y Esgrima (CdU) | 18 | 8 | 5 | 5 | 21:18 | 3 | 29 |
| 7 |
|
Sportivo Las Parejas | 18 | 8 | 4 | 6 | 22:18 | 4 | 28 |
| 8 |
|
Gimnasia y Tiro de Salta | 18 | 7 | 4 | 7 | 14:17 | -3 | 25 |
| 9 |
|
Belgrano de San Francisco | 18 | 7 | 3 | 8 | 25:22 | 3 | 24 |
| 10 |
|
Crucero del Norte | 18 | 6 | 6 | 6 | 16:22 | -6 | 24 |
| 11 |
|
Juventud Antoniana | 18 | 5 | 5 | 8 | 13:22 | -9 | 20 |
| 12 |
|
Unión de Sunchales | 18 | 5 | 3 | 10 | 18:28 | -10 | 18 |
| 13 |
|
Boca Unidos | 17 | 3 | 8 | 6 | 11:18 | -7 | 17 |
| 14 |
|
Defensores Belgrano (VR) | 18 | 4 | 3 | 11 | 15:23 | -8 | 15 |
| 15 |
|
Juventud Unida de Gualeguaychú | 18 | 4 | 3 | 11 | 16:30 | -14 | 15 |
| 16 |
|
Defensores de Pronunciamiento | 18 | 3 | 6 | 9 | 11:26 | -15 | 15 |
| 17 |
|
Atlético Paraná | 18 | 2 | 7 | 9 | 15:26 | -11 | 13 |
| Play-off |
