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| 03.10.2021 | 16:00 | Unión de Sunchales | - | Gimnasia y Esgrima (CdU) | 3:0 (2:0) | |
| 16:00 | Crucero del Norte | - | Racing de Córdoba | 1:2 (0:2) | ||
| 20:00 | Sarmiento de Resistencia | - | Juventud Unida de Gualeguaychú | 3:2 (3:2) | ||
| 20:00 | Defensores de Pronunciamiento | - | Sportivo Las Parejas | 2:1 (2:1) | ||
| 20:00 | Defensores Belgrano (VR) | - | Douglas Haig | 4:3 (4:3) | ||
| 20:00 | Central Norte | - | Chaco For Ever | 2:0 (2:0) | ||
| 04.10.2021 | 00:30 | Belgrano de San Francisco | - | Boca Unidos | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 25 | 15 | 7 | 3 | 41:15 | 26 | 52 |
| 2 |
|
Gimnasia y Tiro de Salta | 24 | 14 | 7 | 3 | 31:16 | 15 | 49 |
| 3 |
|
Central Norte | 24 | 10 | 11 | 3 | 34:21 | 13 | 41 |
| 4 |
|
Chaco For Ever | 25 | 10 | 10 | 5 | 29:19 | 10 | 40 |
| 5 |
|
Sportivo Las Parejas | 24 | 8 | 8 | 8 | 26:24 | 2 | 32 |
| 6 |
|
Defensores de Pronunciamiento | 24 | 8 | 8 | 8 | 26:28 | -2 | 32 |
| 7 |
|
Defensores Belgrano (VR) | 24 | 9 | 5 | 10 | 32:35 | -3 | 32 |
| 8 |
|
Juventud Unida de Gualeguaychú | 24 | 8 | 7 | 9 | 25:30 | -5 | 31 |
| 9 |
|
Unión de Sunchales | 24 | 7 | 9 | 8 | 26:29 | -3 | 30 |
| 10 |
|
Boca Unidos | 24 | 6 | 11 | 7 | 31:31 | 0 | 29 |
| 11 |
|
Sarmiento de Resistencia | 25 | 7 | 8 | 10 | 33:38 | -5 | 29 |
| 12 |
|
Belgrano de San Francisco | 25 | 5 | 10 | 10 | 24:32 | -8 | 25 |
| 13 |
|
Gimnasia y Esgrima (CdU) | 24 | 7 | 4 | 13 | 19:33 | -14 | 25 |
| 14 |
|
Douglas Haig | 24 | 6 | 4 | 14 | 16:24 | -8 | 22 |
| 15 |
|
Crucero del Norte | 24 | 4 | 7 | 13 | 16:34 | -18 | 19 |
| Play-off | |
| Prochaine phase |
