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| 12.09.2022 | 15:00 | Talleres de Córdoba II | - | Atlético Tucumán II | 3:1 (1:1) | |
| 15:00 | San Lorenzo II | - | Colón de Santa Fe II | 2:1 (1:1) | ||
| 16:00 | Arsenal de Sarandí II | - | Gimnasia de La Plata II | 2:1 (1:1) | ||
| 16:00 | Newell's Old Boys II | - | Aldosivi II | 3:1 (3:1) | ||
| 13.09.2022 | 15:00 | Independiente II | - | Sarmiento de Junín II | 4:0 (1:0) | |
| 16:00 | Barracas Central II | - | Huracán II | 1:3 (0:0) | ||
| 16:00 | Tigre II | - | Godoy Cruz II | 2:0 (2:0) | ||
| 16:00 | Patronato de Paraná II | - | Racing Club II | 2:1 (1:0) | ||
| 16:00 | Estudiantes II | - | Rosario Central II | 1:0 (0:0) | ||
| 14.09.2022 | 15:00 | Boca Juniors II | - | Lanús II | 1:1 (0:1) | |
| 15:00 | Central Córdoba SdE II | - | Vélez Sarsfield II | 0:1 (0:0) | ||
| 16:00 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 (0:0) | ||
| 16:00 | Unión de Santa Fe II | - | Platense II | 2:2 (0:2) | ||
| 15.09.2022 | 15:00 | Banfield II | - | River Plate II | 0:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 19 | 13 | 2 | 4 | 36:13 | 23 | 41 |
| 2 |
|
Vélez Sarsfield II | 19 | 12 | 2 | 5 | 33:11 | 22 | 38 |
| 3 |
|
Argentinos Juniors II | 19 | 9 | 7 | 3 | 27:15 | 12 | 34 |
| 4 |
|
Newell's Old Boys II | 19 | 9 | 7 | 3 | 27:18 | 9 | 34 |
| 5 |
|
Huracán II | 19 | 10 | 3 | 6 | 38:29 | 9 | 33 |
| 6 |
|
Tigre II | 19 | 9 | 5 | 5 | 23:20 | 3 | 32 |
| 7 |
|
Independiente II | 19 | 9 | 4 | 6 | 32:24 | 8 | 31 |
| 8 |
|
River Plate II | 19 | 10 | 1 | 8 | 22:17 | 5 | 31 |
| 9 |
|
San Lorenzo II | 19 | 9 | 3 | 7 | 25:22 | 3 | 30 |
| 10 |
|
Defensa y Justicia II | 19 | 9 | 3 | 7 | 21:22 | -1 | 30 |
| 11 |
|
Gimnasia de La Plata II | 19 | 8 | 5 | 6 | 31:25 | 6 | 29 |
| 12 |
|
Lanús II | 19 | 8 | 4 | 7 | 30:31 | -1 | 28 |
| 13 |
|
Rosario Central II | 19 | 7 | 5 | 7 | 31:28 | 3 | 26 |
| 14 |
|
Unión de Santa Fe II | 19 | 6 | 8 | 5 | 19:17 | 2 | 26 |
| 15 |
|
Talleres de Córdoba II | 19 | 7 | 4 | 8 | 25:26 | -1 | 25 |
| 16 |
|
Colón de Santa Fe II | 19 | 6 | 7 | 6 | 24:27 | -3 | 25 |
| 17 |
|
Banfield II | 19 | 6 | 6 | 7 | 16:18 | -2 | 24 |
| 18 |
|
Estudiantes II | 19 | 5 | 8 | 6 | 14:18 | -4 | 23 |
| 19 |
|
Arsenal de Sarandí II | 19 | 5 | 7 | 7 | 19:21 | -2 | 22 |
| 20 |
|
Central Córdoba SdE II | 19 | 6 | 4 | 9 | 18:29 | -11 | 22 |
| 21 |
|
Atlético Tucumán II | 19 | 6 | 3 | 10 | 25:29 | -4 | 21 |
| 22 |
|
Godoy Cruz II | 19 | 5 | 6 | 8 | 24:28 | -4 | 21 |
| 23 |
|
Platense II | 19 | 3 | 10 | 6 | 15:20 | -5 | 19 |
| 24 |
|
Patronato de Paraná II | 19 | 5 | 4 | 10 | 17:30 | -13 | 19 |
| 25 |
|
Racing Club II | 19 | 4 | 6 | 9 | 25:25 | 0 | 18 |
| 26 |
|
Sarmiento de Junín II | 19 | 5 | 3 | 11 | 14:31 | -17 | 18 |
| 27 |
|
Aldosivi II | 19 | 5 | 2 | 12 | 26:41 | -15 | 17 |
| 28 |
|
Barracas Central II | 19 | 5 | 1 | 13 | 12:34 | -22 | 16 |
