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| 27.11.2021 | 13:00 | Patronato de Paraná II | - | Godoy Cruz II | 1:0 (0:0) | |
| 13:00 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 (2:1) | ||
| 13:00 | Platense II | - | Huracán II | 1:0 (1:0) | ||
| 13:00 | Racing Club II | - | Lanús II | 1:1 (1:0) | ||
| 13:00 | Talleres de Córdoba II | - | Aldosivi II | 1:1 (1:1) | ||
| 28.11.2021 | 13:00 | Rosario Central II | - | River Plate II | 2:0 (0:0) | |
| 29.11.2021 | 13:00 | Central Córdoba SdE II | - | Arsenal de Sarandí II | 1:2 (1:0) | |
| 13:00 | Estudiantes II | - | Vélez Sarsfield II | 2:3 (0:3) | ||
| 13:00 | Unión de Santa Fe II | - | Atlético Tucumán II | 0:0 (0:0) | ||
| 30.11.2021 | 13:00 | Argentinos Juniors II | - | Gimnasia de La Plata II | 1:2 (0:1) | |
| 13:00 | Boca Juniors II | - | Newell's Old Boys II | 1:0 (1:0) | ||
| 13:00 | Defensa y Justicia II | - | Colón de Santa Fe II | 0:2 (0:1) | ||
| 01.12.2021 | 13:00 | Banfield II | - | Independiente II | 1:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 23 | 13 | 7 | 3 | 54:22 | 32 | 46 |
| 2 |
|
Colón de Santa Fe II | 23 | 11 | 8 | 4 | 26:16 | 10 | 41 |
| 3 |
|
Rosario Central II | 23 | 11 | 6 | 6 | 44:28 | 16 | 39 |
| 4 |
|
Argentinos Juniors II | 23 | 11 | 6 | 6 | 30:22 | 8 | 39 |
| 5 |
|
Gimnasia de La Plata II | 23 | 11 | 6 | 6 | 35:29 | 6 | 39 |
| 6 |
|
Estudiantes II | 23 | 10 | 8 | 5 | 37:28 | 9 | 38 |
| 7 |
|
Lanús II | 23 | 10 | 6 | 7 | 34:26 | 8 | 36 |
| 8 |
|
Platense II | 23 | 10 | 6 | 7 | 37:30 | 7 | 36 |
| 9 |
|
Vélez Sarsfield II | 22 | 8 | 9 | 5 | 29:26 | 3 | 33 |
| 10 |
|
Newell's Old Boys II | 23 | 8 | 8 | 7 | 28:26 | 2 | 32 |
| 11 |
|
Atlético Tucumán II | 23 | 7 | 10 | 6 | 26:23 | 3 | 31 |
| 12 |
|
Godoy Cruz II | 23 | 7 | 9 | 7 | 24:28 | -4 | 30 |
| 13 |
|
San Lorenzo II | 23 | 7 | 8 | 8 | 27:29 | -2 | 29 |
| 14 |
|
Arsenal de Sarandí II | 23 | 7 | 8 | 8 | 21:24 | -3 | 29 |
| 15 |
|
Banfield II | 23 | 8 | 5 | 10 | 26:33 | -7 | 29 |
| 16 |
|
Talleres de Córdoba II | 22 | 6 | 10 | 6 | 22:23 | -1 | 28 |
| 17 |
|
Independiente II | 23 | 6 | 10 | 7 | 19:22 | -3 | 28 |
| 18 |
|
Sarmiento de Junín II | 23 | 7 | 7 | 9 | 31:37 | -6 | 28 |
| 19 |
|
River Plate II | 23 | 9 | 1 | 13 | 27:33 | -6 | 28 |
| 20 |
|
Huracán II | 23 | 8 | 3 | 12 | 20:25 | -5 | 27 |
| 21 |
|
Defensa y Justicia II | 23 | 6 | 8 | 9 | 25:35 | -10 | 26 |
| 22 |
|
Patronato de Paraná II | 23 | 7 | 5 | 11 | 27:38 | -11 | 26 |
| 23 |
|
Aldosivi II | 23 | 7 | 4 | 12 | 23:31 | -8 | 25 |
| 24 |
|
Racing Club II | 23 | 4 | 9 | 10 | 24:34 | -10 | 21 |
| 25 |
|
Unión de Santa Fe II | 23 | 3 | 11 | 9 | 18:32 | -14 | 20 |
| 26 |
|
Central Córdoba SdE II | 23 | 5 | 4 | 14 | 21:35 | -14 | 19 |
