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| 16.11.2021 | 21:00 | Banfield II | - | Aldosivi II | 0:1 (0:1) | |
| 17.11.2021 | 13:00 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 (0:2) | |
| 13:00 | Estudiantes II | - | Huracán II | 1:2 (1:0) | ||
| 13:00 | Racing Club II | - | Colón de Santa Fe II | 1:1 (1:1) | ||
| 13:00 | Unión de Santa Fe II | - | Defensa y Justicia II | 1:1 (1:1) | ||
| 18.11.2021 | 13:00 | Argentinos Juniors II | - | Godoy Cruz II | 1:1 (1:0) | |
| 13:00 | Boca Juniors II | - | Sarmiento de Junín II | 4:4 (1:2) | ||
| 13:00 | San Lorenzo II | - | Gimnasia de La Plata II | 4:1 (3:1) | ||
| 19.11.2021 | Talleres de Córdoba II | - | Vélez Sarsfield II | pas disputer | ||
| 13:00 | Patronato de Paraná II | - | Lanús II | 5:2 (4:1) | ||
| 13:00 | Central Córdoba SdE II | - | Independiente II | 2:3 (2:2) | ||
| 13:00 | Platense II | - | River Plate II | 5:2 (3:1) | ||
| 20.11.2021 | 13:00 | Rosario Central II | - | Atlético Tucumán II | 4:1 (3:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 21 | 12 | 6 | 3 | 53:22 | 31 | 42 |
| 2 |
|
Argentinos Juniors II | 21 | 11 | 5 | 5 | 28:19 | 9 | 38 |
| 3 |
|
Estudiantes II | 21 | 10 | 7 | 4 | 35:25 | 10 | 37 |
| 4 |
|
Colón de Santa Fe II | 21 | 10 | 7 | 4 | 23:15 | 8 | 37 |
| 5 |
|
Rosario Central II | 21 | 10 | 5 | 6 | 41:27 | 14 | 35 |
| 6 |
|
Lanús II | 21 | 10 | 4 | 7 | 28:20 | 8 | 34 |
| 7 |
|
Gimnasia de La Plata II | 21 | 9 | 6 | 6 | 32:28 | 4 | 33 |
| 8 |
|
Platense II | 21 | 9 | 5 | 7 | 31:25 | 6 | 32 |
| 9 |
|
Newell's Old Boys II | 21 | 8 | 7 | 6 | 27:24 | 3 | 31 |
| 10 |
|
Vélez Sarsfield II | 20 | 7 | 8 | 5 | 25:23 | 2 | 29 |
| 11 |
|
Godoy Cruz II | 21 | 7 | 8 | 6 | 24:27 | -3 | 29 |
| 12 |
|
River Plate II | 21 | 9 | 1 | 11 | 26:29 | -3 | 28 |
| 13 |
|
Banfield II | 21 | 8 | 4 | 9 | 24:29 | -5 | 28 |
| 14 |
|
Atlético Tucumán II | 21 | 6 | 9 | 6 | 22:22 | 0 | 27 |
| 15 |
|
Talleres de Córdoba II | 20 | 6 | 9 | 5 | 21:21 | 0 | 27 |
| 16 |
|
San Lorenzo II | 21 | 6 | 8 | 7 | 24:27 | -3 | 26 |
| 17 |
|
Independiente II | 21 | 6 | 8 | 7 | 18:21 | -3 | 26 |
| 18 |
|
Defensa y Justicia II | 21 | 6 | 8 | 7 | 24:29 | -5 | 26 |
| 19 |
|
Arsenal de Sarandí II | 21 | 6 | 7 | 8 | 19:23 | -4 | 25 |
| 20 |
|
Sarmiento de Junín II | 21 | 6 | 7 | 8 | 27:33 | -6 | 25 |
| 21 |
|
Huracán II | 21 | 7 | 3 | 11 | 19:24 | -5 | 24 |
| 22 |
|
Patronato de Paraná II | 21 | 6 | 5 | 10 | 26:37 | -11 | 23 |
| 23 |
|
Aldosivi II | 21 | 6 | 3 | 12 | 21:30 | -9 | 21 |
| 24 |
|
Central Córdoba SdE II | 21 | 5 | 3 | 13 | 19:32 | -13 | 18 |
| 25 |
|
Unión de Santa Fe II | 21 | 3 | 9 | 9 | 18:32 | -14 | 18 |
| 26 |
|
Racing Club II | 21 | 3 | 8 | 10 | 21:32 | -11 | 17 |
