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| 09.09.2021 | 18:10 | Boca Juniors II | - | Defensa y Justicia II | 3:2 (2:1) | |
| 10.09.2021 | 15:00 | Argentinos Juniors II | - | Patronato de Paraná II | 3:0 (1:0) | |
| 15:00 | Central Córdoba SdE II | - | Atlético Tucumán II | 1:1 (0:1) | ||
| 15:00 | Gimnasia de La Plata II | - | Vélez Sarsfield II | 2:3 (2:3) | ||
| 15:00 | Newell's Old Boys II | - | River Plate II | 0:2 (0:1) | ||
| 15:00 | Talleres de Córdoba II | - | Platense II | 0:0 (0:0) | ||
| 15:00 | Unión de Santa Fe II | - | Estudiantes II | 1:4 (0:2) | ||
| 19:00 | San Lorenzo II | - | Racing Club II | 0:0 (0:0) | ||
| 20:00 | Sarmiento de Junín II | - | Huracán II | 2:1 (0:1) | ||
| 13.09.2021 | 15:00 | Aldosivi II | - | Godoy Cruz II | 1:2 (0:1) | |
| 15:00 | Independiente II | - | Lanús II | 1:0 (0:0) | ||
| 14.09.2021 | 15:00 | Arsenal de Sarandí II | - | Colón de Santa Fe II | 0:0 (0:0) | |
| 15:00 | Banfield II | - | Rosario Central II | 1:3 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes II | 11 | 7 | 4 | 0 | 24:13 | 11 | 25 |
| 2 |
|
Lanús II | 11 | 7 | 1 | 3 | 18:6 | 12 | 22 |
| 3 |
|
Colón de Santa Fe II | 11 | 6 | 4 | 1 | 11:5 | 6 | 22 |
| 4 |
|
Rosario Central II | 11 | 6 | 3 | 2 | 26:14 | 12 | 21 |
| 5 |
|
River Plate II | 11 | 7 | 0 | 4 | 19:10 | 9 | 21 |
| 6 |
|
Boca Juniors II | 11 | 6 | 2 | 3 | 25:12 | 13 | 20 |
| 7 |
|
Gimnasia de La Plata II | 11 | 6 | 1 | 4 | 20:16 | 4 | 19 |
| 8 |
|
Argentinos Juniors II | 11 | 6 | 1 | 4 | 14:12 | 2 | 19 |
| 9 |
|
Banfield II | 11 | 5 | 3 | 3 | 17:16 | 1 | 18 |
| 10 |
|
Platense II | 11 | 5 | 3 | 3 | 12:11 | 1 | 18 |
| 11 |
|
Sarmiento de Junín II | 11 | 5 | 2 | 4 | 16:15 | 1 | 17 |
| 12 |
|
Talleres de Córdoba II | 11 | 4 | 4 | 3 | 12:12 | 0 | 16 |
| 13 |
|
Vélez Sarsfield II | 11 | 4 | 4 | 3 | 14:16 | -2 | 16 |
| 14 |
|
Godoy Cruz II | 11 | 4 | 3 | 4 | 15:16 | -1 | 15 |
| 15 |
|
Defensa y Justicia II | 11 | 4 | 3 | 4 | 12:16 | -4 | 15 |
| 16 |
|
Atlético Tucumán II | 11 | 3 | 5 | 3 | 13:12 | 1 | 14 |
| 17 |
|
Arsenal de Sarandí II | 11 | 3 | 3 | 5 | 10:14 | -4 | 12 |
| 18 |
|
Patronato de Paraná II | 11 | 3 | 3 | 5 | 13:19 | -6 | 12 |
| 19 |
|
Independiente II | 11 | 2 | 5 | 4 | 9:13 | -4 | 11 |
| 20 |
|
San Lorenzo II | 11 | 2 | 5 | 4 | 12:17 | -5 | 11 |
| 21 |
|
Newell's Old Boys II | 11 | 2 | 4 | 5 | 13:19 | -6 | 10 |
| 22 |
|
Unión de Santa Fe II | 11 | 2 | 3 | 6 | 10:19 | -9 | 9 |
| 23 |
|
Huracán II | 11 | 2 | 2 | 7 | 9:15 | -6 | 8 |
| 24 |
|
Racing Club II | 11 | 1 | 5 | 5 | 9:16 | -7 | 8 |
| 25 |
|
Central Córdoba SdE II | 11 | 2 | 1 | 8 | 9:16 | -7 | 7 |
| 26 |
|
Aldosivi II | 11 | 2 | 0 | 9 | 11:23 | -12 | 6 |
