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| 27.07.2021 | 21:30 | Huracán | - | Colón de Santa Fe | 1:1 (1:1) | |
| 23:45 | Aldosivi | - | Racing Club | 0:2 (0:0) | ||
| 28.07.2021 | 02:00 | Boca Juniors | - | San Lorenzo | 0:2 (0:1) | |
| 19:15 | Godoy Cruz | - | Atlético Tucumán | 1:2 (0:0) | ||
| 19:15 | Unión de Santa Fe | - | Banfield | 0:1 (0:0) | ||
| 21:30 | Sarmiento de Junín | - | Platense | 1:0 (0:0) | ||
| 21:30 | Vélez Sarsfield | - | Defensa y Justicia | 0:0 (0:0) | ||
| 23:45 | Independiente | - | Patronato de Paraná | 2:0 (0:0) | ||
| 29.07.2021 | 02:00 | Lanús | - | River Plate | 0:3 (0:2) | |
| 19:15 | Central Córdoba SdE | - | Talleres de Córdoba | 2:1 (1:0) | ||
| 21:30 | Arsenal de Sarandí | - | Argentinos Juniors | 1:0 (0:0) | ||
| 23:45 | Gimnasia de La Plata | - | Rosario Central | 1:0 (1:0) | ||
| 30.07.2021 | 02:00 | Newell's Old Boys | - | Estudiantes | 4:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Lorenzo | 3 | 2 | 1 | 0 | 4:1 | 3 | 7 |
| 2 |
|
Independiente | 3 | 2 | 1 | 0 | 3:0 | 3 | 7 |
| 3 |
|
River Plate | 3 | 2 | 0 | 1 | 8:2 | 6 | 6 |
| 4 |
|
Lanús | 3 | 2 | 0 | 1 | 8:6 | 2 | 6 |
| 5 |
|
Newell's Old Boys | 3 | 2 | 0 | 1 | 7:5 | 2 | 6 |
| 6 |
|
Patronato de Paraná | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 7 |
|
Godoy Cruz | 3 | 2 | 0 | 1 | 5:4 | 1 | 6 |
| 8 |
|
Atlético Tucumán | 3 | 2 | 0 | 1 | 5:5 | 0 | 6 |
| 9 |
|
Racing Club | 3 | 1 | 2 | 0 | 2:0 | 2 | 5 |
| 10 |
|
Gimnasia de La Plata | 3 | 1 | 2 | 0 | 3:2 | 1 | 5 |
| 11 |
|
Banfield | 3 | 1 | 2 | 0 | 2:1 | 1 | 5 |
| 12 |
|
Central Córdoba SdE | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
|
Huracán | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 | |
| 14 |
|
Argentinos Juniors | 3 | 1 | 1 | 1 | 1:1 | 0 | 4 |
| 15 |
|
Arsenal de Sarandí | 3 | 1 | 1 | 1 | 2:3 | -1 | 4 |
| 16 |
|
Colón de Santa Fe | 3 | 1 | 1 | 1 | 4:6 | -2 | 4 |
| 17 |
|
Estudiantes | 3 | 1 | 0 | 2 | 5:5 | 0 | 3 |
|
Talleres de Córdoba | 3 | 1 | 0 | 2 | 5:5 | 0 | 3 | |
| 19 |
|
Rosario Central | 3 | 1 | 0 | 2 | 2:3 | -1 | 3 |
| 20 |
|
Aldosivi | 3 | 1 | 0 | 2 | 1:4 | -3 | 3 |
| 21 |
|
Sarmiento de Junín | 3 | 1 | 0 | 2 | 1:5 | -4 | 3 |
| 22 |
|
Vélez Sarsfield | 3 | 0 | 2 | 1 | 0:1 | -1 | 2 |
| 23 |
|
Boca Juniors | 3 | 0 | 2 | 1 | 1:3 | -2 | 2 |
| 24 |
|
Defensa y Justicia | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 |
|
Platense | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 | |
| 26 |
|
Unión de Santa Fe | 3 | 0 | 1 | 2 | 1:6 | -5 | 1 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
