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| 14.05.2022 | 20:00 | Deportivo Madryn | - | Gimnasia de Mendoza | 2:0 (1:0) | |
| 20:30 | Agropecuario Argentino | - | San Martín de Tucumán | 1:1 (1:1) | ||
| 20:30 | Almagro | - | San Martín de San Juan | 1:0 (1:0) | ||
| 20:30 | Deportivo Maipú | - | Estudiantes de Caseros | 0:1 (0:1) | ||
| 20:30 | Sacachispas | - | Brown de Adrogué | 1:2 (1:1) | ||
| 22:00 | Quilmes | - | Ramón Santamarina | 2:0 (0:0) | ||
| 15.05.2022 | 20:00 | Instituto de Córdoba | - | Defensores de Belgrano | 2:1 (0:0) | |
| 20:30 | Temperley | - | Güemes de SdE | 1:0 (0:0) | ||
| 20:30 | Flandria | - | Deportivo Riestra | 0:0 (0:0) | ||
| 21:30 | Alvarado | - | Chaco For Ever | 0:3 (0:0) | ||
| 21:30 | Estudiantes de Río Cuarto | - | San Telmo | 2:1 (1:0) | ||
| 22:00 | Independiente Rivadavia | - | Atlético Rafaela | 1:0 (1:0) | ||
| 22:10 | Mitre de SdE | - | Chacarita Juniors | 0:3 (0:1) | ||
| 16.05.2022 | 00:10 | Gimnasia de Jujuy | - | Belgrano de Córdoba | 1:0 (0:0) | |
| 20:00 | Nueva Chicago | - | Atlanta | 1:0 (1:0) | ||
| 17.05.2022 | 00:00 | Ferro Carril Oeste | - | Guillermo Brown | 1:0 (1:0) | |
| 00:10 | Deportivo Morón | - | All Boys | 0:0 (0:0) | ||
| 02:10 | Almirante Brown | - | Villa Dálmine | 2:2 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 14 | 11 | 1 | 2 | 19:9 | 10 | 34 |
| 2 |
|
San Martín de Tucumán | 15 | 8 | 5 | 2 | 21:13 | 8 | 29 |
| 3 |
|
Brown de Adrogué | 15 | 7 | 6 | 2 | 21:14 | 7 | 27 |
| 4 |
|
Instituto de Córdoba | 14 | 7 | 6 | 1 | 17:10 | 7 | 27 |
| 5 |
|
Chacarita Juniors | 15 | 7 | 5 | 3 | 28:19 | 9 | 26 |
| 6 |
|
All Boys | 14 | 6 | 7 | 1 | 19:11 | 8 | 25 |
| 7 |
|
Chaco For Ever | 15 | 5 | 9 | 1 | 20:11 | 9 | 24 |
| 8 |
|
Estudiantes de Caseros | 15 | 6 | 6 | 3 | 14:10 | 4 | 24 |
| 9 |
|
Estudiantes de Río Cuarto | 15 | 6 | 6 | 3 | 15:14 | 1 | 24 |
| 10 |
|
Deportivo Madryn | 15 | 6 | 5 | 4 | 22:16 | 6 | 23 |
| 11 |
|
Gimnasia de Mendoza | 14 | 6 | 4 | 4 | 18:10 | 8 | 22 |
| 12 |
|
Quilmes | 14 | 5 | 7 | 2 | 19:14 | 5 | 22 |
| 13 |
|
Deportivo Maipú | 15 | 5 | 7 | 3 | 13:11 | 2 | 22 |
| 14 |
|
Almagro | 15 | 6 | 4 | 5 | 14:16 | -2 | 22 |
| 15 |
|
Agropecuario Argentino | 14 | 5 | 6 | 3 | 15:10 | 5 | 21 |
| 16 |
|
Deportivo Riestra | 14 | 4 | 8 | 2 | 10:10 | 0 | 20 |
| 17 |
|
Guillermo Brown | 15 | 6 | 2 | 7 | 14:15 | -1 | 20 |
| 18 |
|
Nueva Chicago | 15 | 4 | 7 | 4 | 17:15 | 2 | 19 |
| 19 |
|
Almirante Brown | 15 | 4 | 7 | 4 | 18:18 | 0 | 19 |
| 20 |
|
San Martín de San Juan | 15 | 5 | 3 | 7 | 17:17 | 0 | 18 |
| 21 |
|
Independiente Rivadavia | 14 | 5 | 3 | 6 | 17:19 | -2 | 18 |
| 22 |
|
Defensores de Belgrano | 15 | 4 | 6 | 5 | 16:19 | -3 | 18 |
| 23 |
|
Gimnasia de Jujuy | 15 | 4 | 5 | 6 | 14:20 | -6 | 17 |
| 24 |
|
Alvarado | 15 | 4 | 5 | 6 | 16:24 | -8 | 17 |
| 25 |
|
Deportivo Morón | 15 | 3 | 7 | 5 | 9:9 | 0 | 16 |
| 26 |
|
Atlanta | 15 | 3 | 7 | 5 | 15:17 | -2 | 16 |
| 27 |
|
San Telmo | 14 | 3 | 6 | 5 | 15:23 | -8 | 15 |
| 28 |
|
Atlético Rafaela | 15 | 3 | 5 | 7 | 14:15 | -1 | 14 |
| 29 |
|
Mitre de SdE | 14 | 3 | 5 | 6 | 14:16 | -2 | 14 |
| 30 |
|
Ferro Carril Oeste | 14 | 2 | 7 | 5 | 13:18 | -5 | 13 |
| 31 |
|
Temperley | 15 | 3 | 4 | 8 | 12:20 | -8 | 13 |
| 32 |
|
Flandria | 15 | 2 | 6 | 7 | 17:22 | -5 | 12 |
| 33 |
|
Güemes de SdE | 14 | 2 | 6 | 6 | 8:13 | -5 | 12 |
| 34 |
|
Sacachispas | 14 | 1 | 8 | 5 | 12:16 | -4 | 11 |
| 35 |
|
Villa Dálmine | 14 | 1 | 8 | 5 | 14:23 | -9 | 11 |
| 36 |
|
Tristan Suárez | 14 | 1 | 7 | 6 | 15:22 | -7 | 10 |
| 37 |
|
Ramón Santamarina | 15 | 1 | 6 | 8 | 10:23 | -13 | 9 |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
