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| H (Match allé) | Almirante Brown | - | Barracas Central | 0:0 (0:0) | ||
| R (match retour) | Barracas Central | - | Almirante Brown | 3:2 (3:0) | ||
| H (Match allé): 06.12.2021 21:00 | R (match retour): 13.12.2021 21:00 | vainqueur: Barracas Central | ||||
| H (Match allé) | Ferro Carril Oeste | - | Quilmes | 1:1 (0:0) | ||
| R (match retour) | Quilmes | - | Ferro Carril Oeste | 1:0 (0:0) | ||
| H (Match allé): 07.12.2021 01:10 | R (match retour): 14.12.2021 01:10 | vainqueur: Quilmes | ||||
