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| H (Match allé) | Deportivo Morón | - | Quilmes | 2:2 (1:1) | ||
| R (match retour) | Quilmes | - | Deportivo Morón | 5:4 (1:1, 1:1) tab | ||
| H (Match allé): 21.11.2021 23:15 | R (match retour): 27.11.2021 23:10 | vainqueur: Quilmes | ||||
| H (Match allé) | Independiente Rivadavia | - | Almirante Brown | 1:1 (0:0) | ||
| R (match retour) | Almirante Brown | - | Independiente Rivadavia | 1:0 (1:0) | ||
| H (Match allé): 22.11.2021 21:00 | R (match retour): 29.11.2021 21:00 | vainqueur: Almirante Brown | ||||
| H (Match allé) | San Martín de Tucumán | - | Ferro Carril Oeste | 1:3 (1:2) | ||
| R (match retour) | Ferro Carril Oeste | - | San Martín de Tucumán | 0:1 (0:0) | ||
| H (Match allé): 22.11.2021 23:05 | R (match retour): 30.11.2021 01:10 | vainqueur: Ferro Carril Oeste | ||||
