| 2. Journée | 14.08.2021 | Portsmouth FC | - | Crewe Alexandra | 2:0 | ||||
| 5. Journée | 28.08.2021 | Charlton Athletic | - | Crewe Alexandra | 2:0 | ||||
| 7. Journée | 11.09.2021 | Shrewsbury Town | - | Crewe Alexandra | 1:1 | ||||
| 8. Journée | 18.09.2021 | Crewe Alexandra | - | Burton Albion | 2:0 | ||||
| 6. Journée | 21.09.2021 | Crewe Alexandra | - | Morecambe FC | 1:3 | ||||
| 9. Journée | 25.09.2021 | Rotherham United | - | Crewe Alexandra | 1:1 |  |
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| 10. Journée | 28.09.2021 | Plymouth Argyle | - | Crewe Alexandra | 1:1 | ||||
| 11. Journée | 02.10.2021 | Crewe Alexandra | - | Cambridge United | 2:2 | ||||
| 13. Journée | 16.10.2021 | Fleetwood Town | - | Crewe Alexandra | 3:0 | ||||
| 14. Journée | 19.10.2021 | Crewe Alexandra | - | Sunderland AFC | 0:4 | ||||
| 15. Journée | 23.10.2021 | Wycombe Wanderers | - | Crewe Alexandra | 2:1 | ||||
| 16. Journée | 30.10.2021 | Crewe Alexandra | - | Milton Keynes Dons | 1:4 | ||||
| 23. Journée | 01.02.2022 | Gillingham FC | - | Crewe Alexandra | 1:0 | ||||
| 32. Journée | 08.02.2022 | Crewe Alexandra | - | Plymouth Argyle | 1:4 |
Angleterre