| 13. Journée | 24.09.2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 15. Journée | 07.10.2021 | Banfield II | - | River Plate II | 2:0 | ||||
| 21. Journée | 19.11.2021 | Platense II | - | River Plate II | 5:2 | ||||
| 22. Journée | 23.11.2021 | River Plate II | - | Racing Club II | 1:2 | ||||
| 23. Journée | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Journée | 03.12.2021 | River Plate II | - | Defensa y Justicia II | 2:1 | ||||
| 25. Journée | 10.12.2021 | Atlético Tucumán II | - | River Plate II | 1:1 |
Venezuela