| 1. Journée | 18.01.2021 | Boston River | - | Deportivo Maldonado | 5:0 | ||||
| 2. Journée | 22.01.2021 | Rentistas | - | Boston River | 0:1 | ||||
| 3. Journée | 29.01.2021 | Boston River | - | Cerro Largo | 2:1 |  |
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| 4. Journée | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | |
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| 5. Journée | 07.02.2021 | Boston River | - | Peñarol | 1:2 | |
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| 7. Journée | 15.02.2021 | Boston River | - | Montevideo City Torque | 0:3 | |
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| 9. Journée | 23.02.2021 | Boston River | - | Progreso | 2:3 | |
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| 10. Journée | 28.02.2021 | Fénix | - | Boston River | 2:1 | |
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| 11. Journée | 06.03.2021 | Boston River | - | CA Cerro | 2:0 | |
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| 12. Journée | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | |
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| 13. Journée | 19.03.2021 | Boston River | - | Danubio | 1:5 | ||||
| 14. Journée | 25.03.2021 | Nacional | - | Boston River | 1:2 | ||||
| 15. Journée | 29.03.2021 | Boston River | - | Liverpool | 1:0 | |
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Uruguay
Italie