| 1. Journée | 17.07.2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 | ||||
| 2. Journée | 27.07.2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 3. Journée | 30.07.2021 | Newell's Old Boys | - | Estudiantes | 4:2 | ||||
| 7. Journée | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Journée | 25.08.2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
| 10. Journée | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 11. Journée | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Journée | 20.09.2021 | Lanús | - | Newell's Old Boys | 1:2 | ||||
| 13. Journée | 28.09.2021 | Newell's Old Boys | - | Huracán | 0:1 | ||||
| 17. Journée | 21.10.2021 | Newell's Old Boys | - | Aldosivi | 0:0 | ||||
| 18. Journée | 25.10.2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 | ||||
| 23. Journée | 30.11.2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | ||||
| 24. Journée | 07.12.2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Journée | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
Argentine