| 1. Journée | 11.02.2022 | Newell's Old Boys | - | Defensa y Justicia | 1:0 | ||||
| 2. Journée | 15.02.2022 | Argentinos Juniors | - | Newell's Old Boys | 3:0 |  |
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| 3. Journée | 21.02.2022 | Newell's Old Boys | - | River Plate | 0:2 | ||||
| 4. Journée | 28.02.2022 | Talleres de Córdoba | - | Newell's Old Boys | 1:2 | |
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| 5. Journée | 06.03.2022 | Newell's Old Boys | - | Atlético Tucumán | 4:0 | |
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| 6. Journée | 12.03.2022 | Sarmiento de Junín | - | Newell's Old Boys | 2:2 | |
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| 7. Journée | 20.03.2022 | Rosario Central | - | Newell's Old Boys | 0:1 | |
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| 9. Journée | 09.04.2022 | Unión de Santa Fe | - | Newell's Old Boys | 1:0 | |
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| 10. Journée | 16.04.2022 | Newell's Old Boys | - | Patronato de Paraná | 1:0 | ||||
| 11. Journée | 20.04.2022 | Newell's Old Boys | - | Banfield | 1:0 | ||||
| 12. Journée | 24.04.2022 | Racing Club | - | Newell's Old Boys | 0:0 | ||||
| 13. Journée | 28.04.2022 | Newell's Old Boys | - | San Lorenzo | 1:2 | ||||
| 14. Journée | 08.05.2022 | Gimnasia de La Plata | - | Newell's Old Boys | 3:1 | |
Argentine