| 1. Journée | 12.02.2021 | Estudiantes II | - | River Plate II | 1:3 | ||||
| 2. Journée | 19.02.2021 | River Plate II | - | Rosario Central II | 1:1 | ||||
| 3. Journée | 26.02.2021 | Platense II | - | River Plate II | 1:2 |  |
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| 4. Journée | 05.03.2021 | River Plate II | - | Argentinos Juniors II | 1:0 | |
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| 5. Journée | 12.03.2021 | Boca Juniors II | - | River Plate II | 0:1 | |
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| 6. Journée | 19.03.2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 7. Journée | 29.03.2021 | River Plate II | - | Racing Club II | 1:0 | ||||
| 8. Journée | 02.04.2021 | Arsenal de Sarandí II | - | River Plate II | 1:1 | |
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| 9. Journée | 09.04.2021 | River Plate II | - | Colón de Santa Fe II | 7:0 | |
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| 10. Journée | 16.04.2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | |
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| 11. Journée | 23.04.2021 | River Plate II | - | San Lorenzo II | 2:1 | ||||
| 12. Journée | 30.04.2021 | Banfield II | - | River Plate II | 1:2 |
Colombie