| 1. Journée | 11.02.2022 | Unión de Santa Fe II | - | River Plate II | 0:0 | ||||
| 2. Journée | 15.02.2022 | River Plate II | - | Patronato de Paraná II | 1:0 | ||||
| 3. Journée | 19.02.2022 | Newell's Old Boys II | - | River Plate II | 1:2 | ||||
| 4. Journée | 24.02.2022 | River Plate II | - | Racing Club II | 4:2 | ||||
| 5. Journée | 04.03.2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 6. Journée | 10.03.2022 | River Plate II | - | Gimnasia de La Plata II | 2:4 | ||||
| 7. Journée | 18.03.2022 | River Plate II | - | Boca Juniors II | 0:0 |  |
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| 8. Journée | 01.04.2022 | Defensa y Justicia II | - | River Plate II | 2:0 | ||||
| 9. Journée | 09.04.2022 | River Plate II | - | Argentinos Juniors II | 0:0 | ||||
| 10. Journée | 14.04.2022 | Banfield II | - | River Plate II | 2:3 | |
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| 12. Journée | 25.04.2022 | River Plate II | - | Atlético Tucumán II | 4:0 | ||||
| 13. Journée | 29.04.2022 | Sarmiento de Junín II | - | River Plate II | 1:2 |
Argentine