| 1. Journée | 08.08.2021 | AS Saint-Étienne | - | FC Lorient | 1:1 | ||||
| 2. Journée | 15.08.2021 | RC Lens | - | AS Saint-Étienne | 2:2 | ||||
| 3. Journée | 21.08.2021 | AS Saint-Étienne | - | Lille OSC | 1:1 | ||||
| 4. Journée | 28.08.2021 | Olympique Marseille | - | AS Saint-Étienne | 3:1 | ||||
| 5. Journée | 12.09.2021 | Montpellier HSC | - | AS Saint-Étienne | 2:0 | ||||
| 6. Journée | 18.09.2021 | AS Saint-Étienne | - | Girondins Bordeaux | 1:2 | ||||
| 7. Journée | 22.09.2021 | AS Monaco | - | AS Saint-Étienne | 3:1 |  |
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| 9. Journée | 03.10.2021 | AS Saint-Étienne | - | Olympique Lyonnais | 1:1 | ||||
| 10. Journée | 17.10.2021 | RC Strasbourg | - | AS Saint-Étienne | 5:1 | ||||
| 12. Journée | 30.10.2021 | FC Metz | - | AS Saint-Étienne | 1:1 | ||||
| 13. Journée | 07.11.2021 | AS Saint-Étienne | - | Clermont Foot 63 | 3:2 | ||||
| 14. Journée | 21.11.2021 | ESTAC Troyes | - | AS Saint-Étienne | 0:1 |  |
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| 15. Journée | 28.11.2021 | AS Saint-Étienne | - | Paris Saint-Germain | 1:3 | ||||
| 17. Journée | 05.12.2021 | AS Saint-Étienne | - | Stade Rennais | 0:5 | ||||
| 18. Journée | 11.12.2021 | Stade de Reims | - | AS Saint-Étienne | 2:0 |
Angleterre
