| 1. Journée | 07.08.2021 | Scunthorpe United | - | Swindon Town | 1:3 | ||||
| 2. Journée | 14.08.2021 | Rochdale AFC | - | Scunthorpe United | 0:0 | ||||
| 3. Journée | 17.08.2021 | Walsall FC | - | Scunthorpe United | 1:1 | ||||
| 4. Journée | 21.08.2021 | Scunthorpe United | - | Sutton United | 1:1 | ||||
| 5. Journée | 28.08.2021 | Scunthorpe United | - | Tranmere Rovers | 1:0 | ||||
| 6. Journée | 04.09.2021 | Northampton Town | - | Scunthorpe United | 2:0 | ||||
| 9. Journée | 25.09.2021 | Scunthorpe United | - | Port Vale FC | 0:1 | ||||
| 11. Journée | 09.10.2021 | Harrogate Town | - | Scunthorpe United | 6:1 | ||||
| 12. Journée | 16.10.2021 | Scunthorpe United | - | Forest Green Rovers | 0:2 | ||||
| 15. Journée | 30.10.2021 | Colchester United | - | Scunthorpe United | 2:1 | ||||
| 19. Journée | 27.11.2021 | Scunthorpe United | - | Bradford City | 1:1 | ||||
| 20. Journée | 07.12.2021 | Stevenage FC | - | Scunthorpe United | 1:1 | ||||
| 23. Journée | 26.12.2021 | Oldham Athletic | - | Scunthorpe United | 1:3 | ||||
| 25. Journée | 01.01.2022 | Scunthorpe United | - | Carlisle United | 0:1 | ||||
| 26. Journée | 08.01.2022 | Tranmere Rovers | - | Scunthorpe United | 4:0 | ||||
| 29. Journée | 29.01.2022 | Port Vale FC | - | Scunthorpe United | 1:0 |
Angleterre