| 2. Journée | 01.09.2012 | Montevideo Wanderers | - | Defensor Sporting | 0:4 | ||||
| 3. Journée | 15.09.2012 | Defensor Sporting | - | Liverpool | 2:0 |  |
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| 5. Journée | 30.09.2012 | Defensor Sporting | - | Juventud de Las Piedras | 1:1 | ||||
| 6. Journée | 07.10.2012 | El Tanque Sisley | - | Defensor Sporting | 1:1 | ||||
| 7. Journée | 14.10.2012 | Defensor Sporting | - | Racing | 1:0 | ||||
| 11. Journée | 10.11.2012 | Fénix | - | Defensor Sporting | 1:3 | ||||
| 12. Journée | 17.11.2012 | Defensor Sporting | - | Bella Vista | 4:0 | ||||
| 13. Journée | 24.11.2012 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 14. Journée | 01.12.2012 | Defensor Sporting | - | Cerro Largo | 1:0 | ||||
| 15. Journée | 08.12.2012 | Defensor Sporting | - | CA Cerro | 2:0 |
Argentine