| 1. Journée | 07.08.2021 | Sunderland AFC | - | Wigan Athletic | 2:1 |  |
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| 2. Journée | 14.08.2021 | Wigan Athletic | - | Rotherham United | 1:0 | |
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| 3. Journée | 17.08.2021 | Wigan Athletic | - | Wycombe Wanderers | 1:1 | |
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| 4. Journée | 21.08.2021 | Charlton Athletic | - | Wigan Athletic | 0:2 | ||||
| 5. Journée | 28.08.2021 | Wigan Athletic | - | Portsmouth FC | 1:0 | ||||
| 7. Journée | 11.09.2021 | Wigan Athletic | - | Doncaster Rovers | 2:1 | |
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| 8. Journée | 18.09.2021 | Accrington Stanley | - | Wigan Athletic | 1:4 |  |
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| 9. Journée | 25.09.2021 | Wigan Athletic | - | Cheltenham Town | 2:0 | |
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| 10. Journée | 28.09.2021 | Wigan Athletic | - | Sheffield Wednesday | 1:2 | |
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| 11. Journée | 02.10.2021 | Gillingham FC | - | Wigan Athletic | 0:2 | ||||
| 13. Journée | 16.10.2021 | Bolton Wanderers | - | Wigan Athletic | 0:4 | ||||
| 14. Journée | 19.10.2021 | Wigan Athletic | - | Milton Keynes Dons | 1:2 | |
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| 15. Journée | 23.10.2021 | AFC Wimbledon | - | Wigan Athletic | 0:2 | ||||
| 16. Journée | 30.10.2021 | Wigan Athletic | - | Burton Albion | 2:0 | ||||
| 6. Journée | 02.11.2021 | Fleetwood Town | - | Wigan Athletic | 2:3 |
Angleterre