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| 12.02.2022 | 11:00 | Ankaraspor | - | Ergene Velimeşe | 4:1 (2:1) | |
| 11:00 | Bodrumspor | - | Serik Belediyespor | 1:1 (1:0) | ||
| 11:00 | Sarıyer SK | - | Sivas Belediyespor | 1:1 (0:1) | ||
| 13.02.2022 | 11:00 | Bayburt İl Özel İdare | - | Etimesgut Belediyespor | 3:0 (1:0) | |
| 11:00 | Çorum FK | - | Kahramanmaraşspor | 2:1 (2:1) | ||
| 11:00 | 1461 Trabzon FK | - | Diyarbekirspor | 1:0 (1:0) | ||
| 11:00 | Inegölspor | - | Afjet Afyonspor | 2:1 (2:1) | ||
| 11:00 | Somaspor | - | Sakaryaspor | 1:2 (1:1) | ||
| 11:00 | Vanspor FK | - | Turgutluspor | 1:0 (1:0) | ||
| 14.02.2022 | 11:00 | Niğde Anadolu FK | - | Adıyamanspor | 0:3 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 25 | 16 | 7 | 2 | 51:16 | 35 | 55 |
| 2 |
|
1461 Trabzon FK | 25 | 16 | 7 | 2 | 43:18 | 25 | 55 |
| 3 |
|
Sivas Belediyespor | 25 | 13 | 7 | 5 | 45:21 | 24 | 46 |
| 4 |
|
Vanspor FK | 25 | 13 | 6 | 6 | 36:31 | 5 | 45 |
| 5 |
|
Bodrumspor | 25 | 13 | 5 | 7 | 37:21 | 16 | 44 |
| 6 |
|
Bayburt İl Özel İdare | 25 | 13 | 5 | 7 | 36:24 | 12 | 44 |
| 7 |
|
Çorum FK | 25 | 12 | 7 | 6 | 38:22 | 16 | 43 |
| 8 |
|
Afjet Afyonspor | 25 | 11 | 8 | 6 | 46:29 | 17 | 41 |
| 9 |
|
Somaspor | 25 | 12 | 5 | 8 | 40:34 | 6 | 41 |
| 10 |
|
Ankaraspor | 25 | 10 | 8 | 7 | 41:28 | 13 | 38 |
| 11 |
|
Inegölspor | 25 | 10 | 4 | 11 | 31:36 | -5 | 34 |
| 12 |
|
Serik Belediyespor | 25 | 9 | 4 | 12 | 30:34 | -4 | 31 |
| 13 |
|
Etimesgut Belediyespor | 25 | 7 | 8 | 10 | 28:36 | -8 | 29 |
| 14 |
|
Diyarbekirspor | 25 | 8 | 4 | 13 | 26:29 | -3 | 28 |
| 15 |
|
Adıyamanspor | 25 | 9 | 1 | 15 | 35:45 | -10 | 28 |
| 16 |
|
Sarıyer SK | 25 | 7 | 5 | 13 | 28:37 | -9 | 26 |
| 17 |
|
Turgutluspor | 25 | 5 | 8 | 12 | 21:42 | -21 | 23 |
| 18 |
|
Ergene Velimeşe | 25 | 6 | 3 | 16 | 27:51 | -24 | 21 |
| 19 |
|
Kahramanmaraşspor | 25 | 3 | 5 | 17 | 18:59 | -41 | 14 |
| 20 |
|
Niğde Anadolu FK | 25 | 1 | 5 | 19 | 18:62 | -44 | 8 |
| Promotion | |
| Play-off | |
| Relégation |
