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| 10.04.2022 | 14:00 | VV Hoogland | - | RKSV Groene Ster | 1:0 (0:0) | |
| 14:00 | VV Dongen | - | HVV Hollandia | 1:0 (1:0) | ||
| 14:00 | Quick Den Haag | - | VV UNA | 3:1 (3:0) | ||
| 14:00 | Blauw Geel '38 | - | HSC'21 | 2:0 (1:0) | ||
| 14:00 | RKVV DEM | - | OFC Oostzaan | 3:0 (2:0) | ||
| 14:00 | RKVV Westlandia | - | OSS '20 | 1:3 (0:0) | ||
| 14:00 | Unitas Gorinchem | - | JOS Watergraafsmeer | 0:0 (0:0) | ||
| 14:00 | VV Gemert | - | ADO '20 | 2:2 (1:2) | ||
| 14:30 | EVV | - | USV Hercules | 2:3 (1:3) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 24 | 14 | 9 | 1 | 58:35 | 23 | 51 |
| 2 |
|
OFC Oostzaan | 24 | 14 | 3 | 7 | 49:38 | 11 | 45 |
| 3 |
|
RKSV Groene Ster | 24 | 12 | 7 | 5 | 37:30 | 7 | 43 |
| 4 |
|
USV Hercules | 24 | 13 | 3 | 8 | 49:32 | 17 | 42 |
| 5 |
|
VV Dongen | 24 | 11 | 8 | 5 | 41:29 | 12 | 41 |
| 6 |
|
OSS '20 | 24 | 12 | 4 | 8 | 47:35 | 12 | 39 |
| 7 |
|
ADO '20 | 24 | 12 | 3 | 9 | 41:32 | 9 | 39 |
| 8 |
|
VV UNA | 24 | 11 | 4 | 9 | 45:39 | 6 | 37 |
| 9 |
|
Quick Den Haag | 24 | 11 | 2 | 11 | 36:32 | 4 | 35 |
| 10 |
|
Unitas Gorinchem | 24 | 9 | 4 | 11 | 30:44 | -14 | 31 |
| 11 |
|
Blauw Geel '38 | 24 | 9 | 3 | 12 | 42:41 | 1 | 30 |
| 12 |
|
JOS Watergraafsmeer | 24 | 9 | 4 | 11 | 41:45 | -4 | 29 |
| 13 |
|
HSC'21 | 24 | 8 | 3 | 13 | 38:36 | 2 | 27 |
| 14 |
|
RKVV DEM | 24 | 7 | 5 | 12 | 24:39 | -15 | 26 |
| 15 |
|
HVV Hollandia | 24 | 7 | 3 | 14 | 24:36 | -12 | 24 |
| 16 |
|
EVV | 24 | 5 | 9 | 10 | 22:38 | -16 | 24 |
| 17 |
|
VV Hoogland | 24 | 6 | 4 | 14 | 24:49 | -25 | 22 |
| 18 |
|
RKVV Westlandia | 24 | 4 | 6 | 14 | 22:40 | -18 | 18 |
| Promotion | |
| Relégation | |
| Relégation |
