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| 03.04.2022 | 14:00 | ADO '20 | - | OSS '20 | 1:1 (1:0) | |
| 14:00 | HVV Hollandia | - | RKVV DEM | 0:2 (0:0) | ||
| 14:00 | JOS Watergraafsmeer | - | RKSV Groene Ster | 2:3 (1:1) | ||
| 14:00 | VV Gemert | - | Unitas Gorinchem | 3:1 (1:1) | ||
| 14:30 | HSC'21 | - | USV Hercules | 0:3 (0:2) | ||
| 14:30 | EVV | - | VV Hoogland | 2:1 (1:0) | ||
| 14:30 | OFC Oostzaan | - | Blauw Geel '38 | 2:3 (1:1) | ||
| 14:30 | VV UNA | - | RKVV Westlandia | 6:0 (2:0) | ||
| 28.04.2022 | 20:00 | VV Dongen | - | Quick Den Haag | 5:3 (2:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 23 | 14 | 8 | 1 | 56:33 | 23 | 50 |
| 2 |
|
OFC Oostzaan | 23 | 14 | 3 | 6 | 49:35 | 14 | 45 |
| 3 |
|
RKSV Groene Ster | 23 | 12 | 7 | 4 | 37:29 | 8 | 43 |
| 4 |
|
USV Hercules | 23 | 12 | 3 | 8 | 46:30 | 16 | 39 |
| 5 |
|
VV Dongen | 23 | 10 | 8 | 5 | 40:29 | 11 | 38 |
| 6 |
|
ADO '20 | 23 | 12 | 2 | 9 | 39:30 | 9 | 38 |
| 7 |
|
VV UNA | 23 | 11 | 4 | 8 | 44:36 | 8 | 37 |
| 8 |
|
OSS '20 | 23 | 11 | 4 | 8 | 44:34 | 10 | 36 |
| 9 |
|
Quick Den Haag | 23 | 10 | 2 | 11 | 33:31 | 2 | 32 |
| 10 |
|
Unitas Gorinchem | 23 | 9 | 3 | 11 | 30:44 | -14 | 30 |
| 11 |
|
JOS Watergraafsmeer | 23 | 9 | 3 | 11 | 41:45 | -4 | 28 |
| 12 |
|
HSC'21 | 23 | 8 | 3 | 12 | 38:34 | 4 | 27 |
| 13 |
|
Blauw Geel '38 | 23 | 8 | 3 | 12 | 40:41 | -1 | 27 |
| 14 |
|
HVV Hollandia | 23 | 7 | 3 | 13 | 24:35 | -11 | 24 |
| 15 |
|
EVV | 23 | 5 | 9 | 9 | 20:35 | -15 | 24 |
| 16 |
|
RKVV DEM | 23 | 6 | 5 | 12 | 21:39 | -18 | 23 |
| 17 |
|
VV Hoogland | 23 | 5 | 4 | 14 | 23:49 | -26 | 19 |
| 18 |
|
RKVV Westlandia | 23 | 4 | 6 | 13 | 21:37 | -16 | 18 |
| Promotion | |
| Relégation | |
| Relégation |
