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| 19.02.2022 | 14:30 | VVOG Harderwijk | - | Sparta Nijkerk | 1:1 (1:0) | |
| 14:30 | HSV Hoek | - | VV GOES | 2:0 (1:0) | ||
| 14:30 | FC Lisse | - | Harkemase Boys | 4:1 (0:0) | ||
| 14:30 | ACV Assen | - | AFC Ajax Zaterdag | 0:0 (0:0) | ||
| 14:30 | ODIN '59 | - | Excelsior '31 | 5:1 (3:1) | ||
| 14:30 | BVV Barendrecht | - | Ter Leede | 4:2 (2:1) | ||
| 14:30 | DVS'33 | - | VV Sint Bavo | 0:2 (0:0) | ||
| 14:30 | SteDoCo | - | VV Staphorst | 3:0 (1:0) | ||
| 15:00 | VV DOVO Veenendaal | - | Sportlust '46 | 3:1 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Lisse | 15 | 10 | 2 | 3 | 33:17 | 16 | 32 |
| 2 |
|
Sparta Nijkerk | 15 | 9 | 3 | 3 | 28:16 | 12 | 30 |
| 3 |
|
Sportlust '46 | 15 | 9 | 2 | 4 | 32:21 | 11 | 29 |
| 4 |
|
Excelsior '31 | 15 | 8 | 2 | 5 | 30:22 | 8 | 26 |
| 5 |
|
SteDoCo | 15 | 6 | 4 | 5 | 25:20 | 5 | 22 |
| 6 |
|
Harkemase Boys | 15 | 6 | 4 | 5 | 32:28 | 4 | 22 |
| 7 |
|
VV Staphorst | 15 | 6 | 4 | 5 | 21:21 | 0 | 22 |
| 8 |
|
BVV Barendrecht | 15 | 5 | 6 | 4 | 30:26 | 4 | 21 |
| 9 |
|
HSV Hoek | 15 | 6 | 3 | 6 | 24:21 | 3 | 21 |
| 10 |
|
DVS'33 | 15 | 6 | 3 | 6 | 21:18 | 3 | 21 |
| 11 |
|
Ter Leede | 15 | 6 | 3 | 6 | 19:25 | -6 | 21 |
| 12 |
|
ACV Assen | 15 | 5 | 3 | 7 | 19:21 | -2 | 18 |
| 13 |
|
ODIN '59 | 15 | 5 | 3 | 7 | 23:30 | -7 | 18 |
| 14 |
|
AFC Ajax Zaterdag | 15 | 5 | 3 | 7 | 18:28 | -10 | 18 |
| 15 |
|
VV DOVO Veenendaal | 15 | 4 | 4 | 7 | 17:23 | -6 | 16 |
| 16 |
|
VVOG Harderwijk | 15 | 3 | 5 | 7 | 27:38 | -11 | 14 |
| 17 |
|
VV Sint Bavo | 15 | 3 | 4 | 8 | 18:28 | -10 | 13 |
| 18 |
|
VV GOES | 15 | 1 | 6 | 8 | 20:34 | -14 | 9 |
| Promotion | |
| Relégation | |
| Relégation |
